Spinal dura mater: biophysical characteristics relevant to medical device development

被引：38

作者：

Nagel S.J. ^{[1
]}

Reddy C.G. ^{[2
]}

Frizon L.A. ^{[1
]}

Chardon M.K. ^{[3
]}

Holland M. ^{[2
]}

Machado A.G. ^{[1
]}

Gillies G.T. ^{[4
]}

Howard M.A. ^{[2
]}

Wilson S. ^{[2
]}

机构：

[1] Center for Neurological Restoration, Cleveland Clinic, Cleveland, OH

[2] Department of Neurosurgery, University of Iowa Hospitals and Clinics, Iowa City, IA

[3] Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL

[4] Department of Mechanical and Aerospace Engineering, University of Virginia, Charlottesville, VA

来源：

Journal of Medical Engineering and Technology | 2018年 / 42卷 / 02期

基金：

美国国家卫生研究院;

关键词：

biophysical characteristics; Dura mater; electric stimulation; prostheses and implants; spine surgery;

D O I：

10.1080/03091902.2018.1435745

中图分类号：

学科分类号：

摘要：

Understanding the relevant biophysical properties of the spinal dura mater is essential to the design of medical devices that will directly interact with this membrane or influence the contents of the intradural space. We searched the literature and reviewed the pertinent characteristics for the design, construction, testing, and imaging of novel devices intended to perforate, integrate, adhere or reside within or outside of the spinal dura mater. The spinal dura mater is a thin tubular membrane composed of collagen and elastin fibres that varies in circumference along its length. Its mechanical properties have been well-described, with the longitudinal tensile strength exceeding the transverse strength. Data on the bioelectric, biomagnetic, optical and thermal characteristics of the spinal dura are limited and sometimes taken to be similar to those of water. While various modalities are available to visualise the spinal dura, magnetic resonance remains the best modality to segment its structure. The reaction of the spinal dura to imposition of a foreign body or other manipulations of it may compromise its biomechanical and immune-protective benefits. Therefore, dural sealants and replacements are of particular clinical, research and commercial interest. In conclusion, existing devices that are in clinical use for spinal cord stimulation, intrathecal access or intradural implantation largely adhere to traditional designs and their attendant limitations. However, if future devices are built with an understanding of the dura’s properties incorporated more fully into the designs, there is potential for improved performance. © 2018 Informa UK Limited, trading as Taylor & Francis Group.

引用

页码：128 / 139

页数：11

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