Supramolecular cyclodextrin hydrogel as bone repair material

被引：0
|
作者：
Wang W. [1 ]
Lin Z. [1 ]
Xu L. [1 ]
Ding C. [1 ]
Li J. [1 ]
机构：
[1] College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu
来源：
Gaofenzi Cailiao Kexue Yu Gongcheng/Polymeric Materials Science and Engineering | 2016年 / 32卷 / 08期
关键词：
Amantadine; Bone repair; Cyclodextrin; Hydrogel; Supramolecular interaction;
D O I：
10.16865/j.cnki.1000-7555.2016.08.006
中图分类号：
学科分类号：
摘要：
β-Cyclodextrin polymer was synthesized as host molecule and a polymer containing amantadine and alendronate group was synthesized as guest molecule. The chemical structure was characterized by 1H-NMR. Then, a type of supramolecular hydrogel was formed through the host-guest molecular interaction and physical crosslinked by β- cyclodextrins and amantadine. The hydrodynamic diameter distribution was characterized by dynamic light scattering(DLS), the results show that β-cyclodextrin polymer has an uniform distribution as the average particle size is 8.773 nm. The hydrogel adhesive property performs strongest when the host-guest ratio is 8∶1. The gelation process of hydrogels was verified by rheological test. Amantadine in the system can provide strong adhesion between the gel and bone trauma interface, thus this system could be used for injectable bone repair hydrogels. © 2016, Editorial Board of Polymer Materials Science & Engineering. All right reserved.
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页码：28 / 31and37
页数：3109
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