In order to facilitate the medical laser transmission, in this paper, we've plastically bent two groups of sapphire fibers with diameters of 550 μm and 750 μm by means of CO2 lasers, the average bending radius is 3.0 mm, the additional loss caused by a single bend is less than 0.1 dB at 900 nm, the damage threshold is higher than 30 MW/cm2 for Nd:YAG laser pulses. Experimental results show that plastically bent sapphire fibers can meet the demands of medical laser transmission with much smaller output fiber-tip sizes, and improve the flexibility of fiber-optic laser transmission systems.