Research progress on improving the tumor-targeting of photosensitizers in photodynamic therapy

被引：0
作者：
Yang Y. [1 ]
Zhao X. [1 ]
Fan J. [1 ,2 ]
Peng X. [1 ]
机构：
[1] State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian
[2] Ningbo Institute of Dalian University of Technology, Ningbo
来源：
Huagong Xuebao/CIESC Journal | 2021年 / 72卷 / 01期
关键词：
Activatable photosensitizers; Photodynamic therapy; Targeting photosensitizers; Tumor selectivity;
D O I：
10.11949/0438-1157.20201047
中图分类号：
学科分类号：
摘要：
Due to the advantages of minimal invasiveness, high temporal and spatial selectivity, and repeated application without drug resistance, photodynamic therapy is considered to be a promising new cancer treatment method. However, traditional photosensitizers possess poor tumor targeting ability and always result in non-specific photodamage to adjacent normal tissues, which greatly limits its clinical application. Constructing the targeting photosensitizers or activatable photosensitizers is an effective way to improve the tumor selectivity of photosensitizers. This paper summarizes the current research progress of targeting photosensitizers and activatable photosensitizers, and gives the prospection of the challenges in future. © 2021, Editorial Board of CIESC Journal. All right reserved.
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页码：1 / 13
页数：12
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