Ion exchange kinetics and column behavior for thymopentin adsorption on NH-1 resin

被引：0

作者：

Li, Xin ^{[1
]}

Shi, Jun ^{[1
]}

Ruan, Wenhui ^{[1
]}

Shen, Shubao ^{[1
]}

Ying, Hanjie ^{[1
]}

机构：

[1] College of Life Science and Pharmaceutical Engineering, Nanjing University of Technology, Nanjing 210009, China

来源：

Lizi Jiaohuan Yu Xifu/Ion Exchange and Adsorption | 2007年 / 23卷 / 03期

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摘要：

Ion exchange kinetics and column behavior were investigated for thymopentin (TP5) on a gel-type cation exchange resin (NH-1). Langmuir isotherm model was well fitted to the ion exchange equilibrium between TP5 and NH-1 resin at pH 2.0. The maximum adsorption capacity was 221.07 mg/g wet resin. Intraparticle diffusion was rate controlling for TP5 into NH-1 resin at pH 2.0 and intraparticle diffusivity of TP5 was 4.50 × 10-9 cm2/s. Comparison between Nernst-Planck kinetic model and Fick kinetic model, Fick's model was suitable to describe the diffusion of TP5 into NH-1 resin and the effective diffusivity was 5.58 × 10-9 cm2/s. Taking into account intraparticle diffusion, axial dispersion, nonlinear equilibrium and external mass transfer, column behaviors were suitably described by a mathematical model of fixed bed adsorption.

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页码：208 / 215