Hormetic mechanism of sulfonamides on Aliivibrio fischeri luminescence based on a bacterial cell-cell communication

被引：11
|
作者：
Yao Z. [1 ]
Wang D. [1 ,2 ]
Wu X. [1 ,3 ]
Lin Z. [1 ,4 ,5 ,6 ]
Long X. [1 ]
Liu Y. [1 ,4 ,5 ]
机构：
[1] State Key Laboratory of Pollution Control and Resource Reuse, College of Environmental Science and Engineering, Tongji University, Shanghai
[2] School of Environment, Jinan University, Guangzhou
[3] College of Marine Ecology and Environment, Shanghai Ocean University, Shanghai
[4] Shanghai Institute of Pollution Control and Ecological Security, Shanghai
[5] Shanghai Key Lab of Chemical Assessment and Sustainability, Shanghai
[6] State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences
来源：
Chemosphere | 2019年 / 215卷
基金：
中国国家自然科学基金;
关键词：
Aliivibrio fischeri; Hormesis; Luminescence; Quorum sensing; Sulfonamides;
D O I：
10.1016/j.chemosphere.2018.10.045
中图分类号：
学科分类号：
摘要：
Hormesis is a biphasic dose-response model with low-dose stimulation and high-dose inhibition. The mechanism for hormesis remains inconclusive, although it is becoming a central concept in toxicology. In this paper, the hormetic mechanism of sulfachloropyridazine (SCP) on Aliivibrio fischeri (A. fischeri) luminescence was explored by investigating into the interference of SCP with the bacterial quorum sensing (QS) communications. It was revealed that the SCP-induced hormesis on luminescence was due to its action on LitR – a key protein that connects lux and ain QS communications in A. fischeri. It was suggested SCP acted on LitR proteins to change its active forms, which subsequently induced hormetic effects on luxR (QS signal receptor) and thereby the luminescence. It is the first time that the hormetic mechanism based on bacterial QS was proposed, which provides a novel insight into the essence of the hormesis on A. fischeri luminescence. © 2018 Elsevier Ltd
引用
收藏
页码：793 / 799
页数：6
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