Investigation on Liposome-Coated Multi-Responsive PDMAEMA Nanogels

被引：0
|
作者：
Deng L. [1 ]
Zhao X. [1 ]
Dong A. [1 ,2 ]
Zhang J. [1 ,3 ]
机构：
[1] School of Chemical Engineering and Technology, Tianjin University, Tianjin
[2] Collaborative Innovation Center of Chemical Science and Engineering(Tianjin), Tianjin
[3] Tianjin Key Laboratory of Membrane Science and Desalination Technology, Tianjin University, Tianjin
来源：
Tianjin Daxue Xuebao (Ziran Kexue yu Gongcheng Jishu Ban)/Journal of Tianjin University Science and Technology | 2019年 / 52卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Drug release; Liposome; Multi-responsive; Nanogel; Poly(2-(dimethylamino)ethyl methacrylate)(PDMAEMA);
D O I：
10.11784/tdxbz201803070
中图分类号：
学科分类号：
摘要：
The environment-responsive release behavior of drugs in nanocarriers is of great significance in biomedicine.Using liposome as a template, pH and temperature dual-responsive 2-(dimethylamino)ethyl methacrylate(DMAEMA)as a monomer, and hydrophilic redox-cleavable cystine methacrylate(CDA)as a crosslinking agent, liposome-coated pH, temperature and redox multi-responsive PDMAEMA nanogels(lipogels)were prepared by in situ template polymerization.The morphology of lipogels was observed by transmission electron micros-copy(TEM).The effects of different stimulus conditions and bovine serum albumin(BSA)on the size of lipogels were measured by laser particle sizer.Using doxorubicin hydrochloride as a hydrophilic drug model, the multi-stimulated drug release behavior of lipogels was investigated.The results show that lipogels are uniform spherical structure, and their size increases as the pH or temperature decreases.Lipogels become fragmented when treated with a reducing agent.Meanwhile, lipogels have good anti-protein adsorption stability and blood compatibility.The drug release behavior indicates that lipogels are multi-responsive to pH, redox and temperature. © 2019, Editorial Board of Journal of Tianjin University(Science and Technology). All right reserved.
引用
收藏
页码：7 / 12
页数：5
相关论文
共 11 条
  • [1] Soni K.S., Desale S.S., Bronich T.K., Nanogels: An overview of properties, biomedical applications and obstacles to clinical translation, Journal of Controlled Release, 240, pp. 109-126, (2016)
  • [2] Li Y., Maciel D., Rodrigues J., Et al., Biodegradable polymer nanogels for drug/nucleic acid delivery, Chemical Reviews, 115, 16, pp. 8564-8608, (2015)
  • [3] Raemdonck K., Demeester J., Smedt S.D., Advanced nanogel engineering for drug delivery, Soft Matter, 5, 4, pp. 707-715, (2009)
  • [4] Ramos J., Forcada J., Hidalgo-Alvarez R., Cationic polymer nanoparticles and nanogels: From synthesis to biotechnological applications, Chemical Reviews, 114, 1, pp. 367-428, (2014)
  • [5] Mandal B., Bhattacharjee H., Mittal N., Et al., Core-shell-type lipid-polymer hybrid nanoparticles as a drug delivery platform, Nanomedicine: Nanotechnology, Biology, and Medicine, 9, 4, pp. 474-491, (2013)
  • [6] Liu X., Situ A., Kang Y., Et al., Irinotecan delivery by lipid-coated mesoporous silica nanoparticles shows improved efficacy and safety over liposomes for pancreatic cancer, ACS Nano, 10, 2, pp. 2702-2715, (2016)
  • [7] Kazakov S., Liposome-nanogel structures for future pharmaceutical applications: An updated review, Current Pharmaceutical Design, 22, 10, pp. 1391-1413, (2016)
  • [8] Zhang Y., Zhang J., Chen W., Et al., Erythrocyte membrane-coated nanogel for combinatorial antiviru-lence and responsive antimicrobial delivery against staphylococcus aureus infection, Journal of Contro-lled Release, 263, pp. 185-191, (2017)
  • [9] Zhang J., Gao W., Fang R.H., Et al., Synthesis of nanogels via cell membrane-templated polymerization, Small, 11, 34, pp. 4309-4313, (2015)
  • [10] Pikabea A., Aguirre G., Miranda J.I., Et al., Understanding of nanogels swelling behavior through a deep insight into their morphology, Journal of Polymer Science Part A: Polymer Chemistry, 53, 17, pp. 2017-2025, (2015)
12