Optimization of Biosynthesis of Silver Oxide Nanoparticles and Its Anticancer Activity

被引：21

作者：

Karunagaran V. ^{[1
]}

Rajendran K. ^{[1
]}

Sen S. ^{[1
]}

机构：

[1] Industrial Biotechnology Division, School of Bio Science and Technology, VIT University, Vellore

来源：

Sen, Shampa (shampasen@vit.ac.in) | 2017年 / World Scientific卷 / 16期

关键词：

anticancer; Bacillus thuringiensis; cytotoxicity; Silver oxide nanoparticle;

D O I：

10.1142/S0219581X17500181

中图分类号：

学科分类号：

摘要：

Silver oxide nanoparticle can be synthesized by chemical and biological methods. Biological synthesis has emerged as an exciting, ecofriendly approach. However, the process tends to be slow when we consider its industrial applicability. The development of reliable method for rapid synthesis of nanoparticles is one of the significant zones of interests in current nanotechnological research. In this paper, optimization of physiochemical parameters for rapid silver oxide nanoparticle synthesis using Bacillus thuringiensis SSV1 culture supernatant has been elucidated. Spherical-shaped silver oxide nanoparticles with an average particle size of 30nm were obtained. The cytotoxic effect of silver oxide nanoparticles was studied against HepG2 and Chang liver cell lines by MTT assay. These nanoparticles showed dose-dependent response on HepG2 (IC50=0.47μg/mL) and Chang liver cells (IC50=1.11μg/mL). © 2017 World Scientific Publishing Company.

引用

页码：5 / 6

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