Determination of benzo(a)pyrene in mainstream cigarette smoke by GC-QqQ-MS/MS

被引：0

作者：

Wei, Zhao ^{[1
]}

Sun, Hai-Feng ^{[1
]}

Chen, Jia-Bing ^{[1
]}

Xie, Tao ^{[1
]}

Wang, Fang ^{[1
]}

机构：

[1] Shenzhen Tobacco Industry LTD. CO.

来源：

Sun, H.-F. (58809077@qq.com) | 1600年 / Chinese Society for Mass Spectrometry卷 / 34期

关键词：

Benzo (a) pyrene; GC-MS/MS; Mainstream cigarette smoke; MRM; Triple quadrupole(QqQ);

D O I：

10.7538/zpxb.2013.34.02.0110

中图分类号：

学科分类号：

摘要：

A GC-QqQ-MS/MS method for the analysis of benzo(a)pyrene in mainstream cig-arette smoke was demonstrated. The total particulate matter (TPM) of 20 cigarettes in ma-instream smoke were trapped by Cambridge filter pad under standard smoking condition and extracted by cyclohexane with internal standard (ISTD). The solution was analyzed by GC-QqQ-MS/MS with positive ESI under multiple reaction monitoring (MRM) mode after be-ing cleaned upon solid phase extraction and determined by ISTD method under the optimized conditions. The calibration curves show good linearity for benzo(a)pyrene in the concentra-tion ranges of 0.4-20 μg/cig and the correlation coefficient is 0.99992. The LOQ is 0.073μg/L, the largest repeatability coefficient of variation is 3.71%, and the standard recovery rates are 95.7%-103.9%. Ease of operation, shorter procedure and little solvent make it suitable for benzo(a)pyrene determination, especially for low tar cigarettes.

引用

页码：110 / 114

页数：4

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