Synthesis of 14C-labeled E4010

被引：1

作者：

Watanabe, N. ^{[1
]}

Tokumura, T. ^{[1
]}

Nakamura, T. ^{[1
]}

机构：

[1] Tsukuba Research Laboratories, Eisai Co., Ltd., 5-1-3 Tokodai, Tsukuba, Ibaraki 300-2635, Japan

来源：

Journal of Labelled Compounds and Radiopharmaceuticals | 2001年 / 44卷 / 12期

关键词：

D O I：

10.1002/jlcr.509

中图分类号：

学科分类号：

摘要：

14C-Labeled E4010, [4-(3-chloro-4-methoxybenzyl)amino-1-(4-hydroxy) -piperidino]-6-[4-14C]phthalazinecarbonitrile monohydrochloride was synthesized for drug metabolism and pharmacokinetic studies using [1-chloro-4-(3-chloro-4-methoxybenzyl)amino]-6-[4- 14C]phthahizinecarbonitrile as the starting material. The radiochemical yield was 33.4%. The specific radioactivity and radiochemical purity, as determined by radio-HPLC and LSC, were 4.77 MBq/ mg and 99.8%, respectively. Copyright © 2001 John Wiley & Sons, Ltd.

引用

页码：843 / 847