Digital Twins Generated by Artificial Intelligence in Personalized Healthcare

Featured Application Featured Application: The potential application of the work relates to novel digital twins of patients or their organs based on artificial intelligence.Abstract Digital society strategies in healthcare include the rapid development of digital twins (DTs) for patients and human organs in medical research and the use of artificial intelligence (AI) in clinical practice to develop effective treatments in a cheaper, quicker, and more effective manner. This is facilitated by the availability of large historical datasets from previous clinical trials and other real-world data sources (e.g., patient biometrics collected from wearable devices). DTs can use AI models to create predictions of future health outcomes for an individual patient in the form of an AI-generated digital twin to support the rapid assessment of in silico intervention strategies. DTs are gaining the ability to update in real time in relation to their corresponding physical patients and connect to multiple diagnostic and therapeutic devices. Support for this form of personalized medicine is necessary due to the complex technological challenges, regulatory perspectives, and complex issues of security and trust in this approach. The challenge is also to combine different datasets and omics to quickly interpret large datasets in order to generate health and disease indicators and to improve sampling and longitudinal analysis. It is possible to improve patient care through various means (simulated clinical trials, disease prediction, the remote monitoring of apatient's condition, treatment progress, and adjustments to the treatment plan), especially in the environments of smart cities and smart territories and through the wider use of 6G, blockchain (and soon maybe quantum cryptography), and the Internet of Things (IoT), as well as through medical technologies, such as multiomics. From a practical point of view, this requires not only efficient validation but also seamless integration with the existing healthcare infrastructure.