Fabrication technology of tissue engineering scaffold based on rapid prototyping

被引:0
|
作者
Yan Y. [1 ,2 ]
Li S. [1 ,2 ]
Xiong Z. [1 ,2 ]
Wang X. [1 ,2 ]
Zhang T. [1 ,2 ]
Zhang R. [1 ,2 ]
机构
[1] Department of Mechanical Engineering, Tsinghua University
[2] Key Laboratory for Advanced Materials Processing Technology of Ministry of Education, Tsinghua University
关键词
Bio-manufacturing; Rapid prototyping; Scaffold; Tissue engineering;
D O I
10.3901/JME.2010.05.093
中图分类号
学科分类号
摘要
Tissue engineering is an important development stage of bio-manufacturing. It constructs the tissue/organs by firstly fabricating the biomaterial scaffolds, and then planting the cells on them. The performance of the scaffold is very important to the application of tissue engineering. Compared to traditional scaffold manufacturing methods, rapid prototyping technology based on dispersed-accumulated principle manufactures scaffold that has high degree of personality: the porosity, the mechanical properties, the biocompatibility and biodegradation characteristic can be set through parameter design and material selection. Therefore it is very suitable for construction of structural tissue/organs. Here kinds of tissue engineering scaffold fabricating technologies based on rapid prototyping are introduced; their features and applications are summarized; their advantages and disadvantages are analyzed and discussed. © 2010 Journal of Mechanical Engineering.
引用
收藏
页码:93 / 98
页数:5
相关论文
共 24 条
  • [1] Yan Y., Liu H., Li S., Et al., Development and trend of biomanufacturing, Bulletin of National Natural Science Foundation of China, 2, pp. 65-68, (2007)
  • [2] Langer R., Vacanti J.P., Tissue engineering, Science, 260, 5110, pp. 920-926, (1993)
  • [3] Kruth J.P., Leu M.C., Nakagawa T., Progress in additive manufacturing and rapid prototyping, Annals of CIRP, 47, 2, pp. 525-540, (1998)
  • [4] Kim S.S., Utsunomiya H., Koski J.A., Et al., Survival and function of hepatocytes on a novel three-dimensional synthetic biodegradable polymer scaffold with an intrinsic network of channels, Annals of Surgery, 228, 1, pp. 8-13, (1998)
  • [5] Lam C.X.F., Mo X.M., Teoh S.H., Et al., Scaffold development using 3D printing with a starch-based polymer, Materials Science & Engineering C-Biomimetic and Supramolecular Systems, 20, 1-2, pp. 49-56, (2002)
  • [6] Sherwood J.K., Riley S.L., Palazzolo R., Et al., A three-dimensional osteochondral composite scaffold for articular cartilage repair, Biomaterials, 23, 24, pp. 4739-4751, (2002)
  • [7] Landers R., Mulhaupt R., Desktop manufacturing of complex objects, prototypes and biomedical scaffolds by means of computer-assisted design combined with computer-guided 3D plotting of polymers and reactive oligomers, Macromolecular Materials and Engineering, 282, 9, pp. 17-21, (2000)
  • [8] Landers R., Hubner U., Schmelzeisen R., Et al., Rapid prototyping of scaffolds derived from thermoreversible hydrogels and tailored for applications in tissue engineering, Biomaterials, 23, 23, pp. 4437-4447, (2002)
  • [9] Xiong Z., Low-temperature deposition manufacturing and fundamental research of bone tissue engineering scaffolds, (2003)
  • [10] Xiong Z., Yan Y., Wang S., Et al., Fabrication of porous scaffolds for bone tissue engineering via low-temperature deposition, Scripta Materialia, 46, 11, pp. 771-776, (2002)