The Apex bileaflet mechanical heart valve

被引：2
作者：
Mohammadi H. [1 ]
Bhullar A. [1 ]
机构：
[1] Faculty of Applied Science, The Heart Valve Performance Laboratory, School of Engineering, University of British Columbia, Kelowna
来源：
Journal of Medical Engineering and Technology | 2021年 / 45卷 / 01期
基金：
加拿大自然科学与工程研究理事会;
关键词：
closing volume; Mechanical heart valves; novel design; SJM valve;
D O I：
10.1080/03091902.2020.1853835
中图分类号：
学科分类号：
摘要：
Mechanical Heart Valves (MHVs) are known for their excellent lifespan and feasibly are the most reliable and stable valves amongst all prosthetic valves. Successful bileaflet MHVs such as the St. Jude Medical (SJM) are known for providing central blood flow and minimal pressure drop across the valve. However, due to their non-physiological flow conditions, they still suffer from hemodynamic complications, that is, red blood cell (RBC) lysis and/or thrombogenicity, to date. Our hypothesis is that the design of MHVs can be improved so that their hemodynamics can be comparable to those of tissue valves. In this study, a new concept for the design of MHVs is proposed. To accomplish this, we identified the major design limitations of bileaflet MHVs, such as the gold standard SJM valve as well as the believed contributing factors to their thrombogenicity. We developed a novel design architecture for bileaflet MHVs that addressed these limitations, and from it, the Apex Valve (AV). Our experimental assessment of the AV found that its hemodynamics were closer to that of a bioprosthetic valve than of a bileaflet MHV. This design has been filed as a US Provisional Patent. © 2021 Informa UK Limited, trading as Taylor & Francis Group.
引用
收藏
页码：41 / 51
页数：10
相关论文
共 19 条
  • [11] Dasi L., Ge L., Simon H., Et al., Vorticity dynamics of a bileaflet MHV in an axisymmetric aorta, Phys Fluids, 19, 6, (2007)
  • [12] Dumont K., Vierendeels J., Kaminsky R., Et al., Comparison of the hemodynamic and thrombogenic performance of two bileaflet mechanical heart valves using a CFD/FSI model, J Biomech Eng, 129, 4, pp. 558-565, (2007)
  • [13] Scotten L.S., Siegel R., Thrombogenic potential of transcatheter aortic valve implantation with trivial paravalvular leakage, Ann Transl Med, 2, 5, (2014)
  • [14] Bluestein D., Yin W., Affeld K., Et al., Flow-induced platelet activation in a MHV, J Heart Valve Dis, 13, 3, pp. 501-508, (2004)
  • [15] Alemu Y., Bluestein D., Flow-induced platelet activation and damage accumulation in a mechanical heart valve: numerical studies, Artif Organs, 31, 9, pp. 677-688, (2007)
  • [16] Alemu Y., Girdhar G., Xenos M., Et al., Design optimization of a MHV for reducing valve thrombogenicity–a case study with ATS valve, Saio J, 56, 5, pp. 389-396, (2010)
  • [17] Ge L., Jones S.C., Sotiropoulos F., Et al., Numerical simulation of flow in MHVs: grid resolution and the assumption of flow symmetry, J Biomech Eng, 125, 5, pp. 709-718, (2003)
  • [18] Sotiropoulos F., Borazjani I., A review of state-of-the-art numerical methods for simulating flow through MHVs, Med Biol Eng Comput, 47, 3, pp. 245-256, (2009)
  • [19] Mohammadi H., Fradet G., Oval housing for the St. Jude medical bileaflet MHV, IMECH, Part H, J Eng Med, 1, (2017)
12