Silver-catalyzed cascade cyclization for the synthesis of 4-aminotetrahydrocarbazole

被引：0

作者：

Zhang, Jingjing ^{[1
,2
]}

Xu, Xinxin ^{[2
]}

Yang, Kangkang ^{[2
]}

Li, Mingxing ^{[2
]}

Liu, Yuxiu ^{[2
]}

Song, Hongjian ^{[2
]}

Wang, Qingmin ^{[2
]}

机构：

[1] Tianjin Agr Univ, Minist Agr & Rural Affairs, Key Lab Smart Breeding Coconstruct Minist & Prov, Tianjin 300384, Peoples R China

[2] Nankai Univ, Res Inst Elemento Organ Chem, State Key Lab Elemento Organ Chem, Frontiers Sci Ctr New Organ Matter,Coll Chem, Tianjin 300071, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2024年 / 60卷 / 86期

关键词：

Cyclization;

D O I：

10.1039/d4cc03723e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A silver-catalyzed cascade cyclization strategy has been developed for the synthesis of 4-aminotetrahydrocarbazole, a common core structure found in various alkaloids. This target molecule can be synthesized through a one-step tandem cyclization reaction, thereby eliminating the need for a prior synthesis of tetrahydrocarbazole. Furthermore, the use of chiral tert-butylsulfinamide facilitates in situ chiral resolution of the resulting product. A straightforward method for accessing substituted carbazoles via a silver-catalyzed cascade cyclization reaction was developed. This practical method can be used for the rapid synthesis of valuable alkaloids containing 4-aminotetrahydrocarbazole.

引用

页码：12573 / 12576

页数：4

共 32 条

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