CircIQCH Contributes to the Progression of Breast Cancer by Elevating NFIB Through Decoying miR-139-5p

被引：0

作者：

Shang Y. ^{[1
]}

Li X. ^{[1
]}

Du Q. ^{[1
]}

Zhao Y. ^{[1
]}

Li Y. ^{[1
]}

机构：

[1] Department of Breast Surgery, the Fourth Hospital of Shijiazhuang, Shijiazhuang

来源：

Environmental Toxicology | 2024年 / 39卷 / 11期

关键词：

breast cancer; circIQCH; miR-139-5p; NFIB;

D O I：

10.1002/tox.24358

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Circular RNAs (circRNAs) are implicated in the progression of breast cancer (BC). However, the explorations on circRNA IQ motif containing H (circIQCH) in BC progression remain limited. Functional experiments were conducted using in vitro and murine xenograft model assays, respectively. Dual-luciferase reporter assay and RIP assay detected the associations among circIQCH, miR-139-5p, and nuclear factor IB (NFIB). CircIQCH was upregulated in BC, and the silencing of circIQCH repressed BC cell growth, metastasis, and autophagy, arrested cell cycle, promoted cell apoptosis in vitro, and blocked tumor growth in vivo. CircIQCH positively modulated NFIB expression by sponging miR-139-5p. Moreover, the deletion of miR-139-5p abated the action of circIQCH deficiency on BC cell malignant behaviors. Overexpression of miR-139-5p repressed the malignant characteristics of BC cells, while these impacts were abolished by elevating NFIB. Collectively, CircIQCH functioned as an oncogene in BC through upregulating NFIB expression by sponging miR-139-5p. © 2024 Wiley Periodicals LLC.

引用

页码：4832 / 4843

页数：11

共 34 条

[11]

Huang X., Song C., Zhang J., Zhu L., Tang H., Circular RNAs in Breast Cancer Diagnosis, Treatment and Prognosis, Oncology Research, 32, 2, pp. 241-249, (2023)

[12]

Zhou H., Tang G., Zhao M., Et al., circFBXL5 Promotes Breast Cancer Progression by Sponging miR-660, Journal of Cellular and Molecular Medicine, 24, 1, pp. 356-361, (2020)

[13]

Wang S., Xue X., Wang R., Et al., CircZNF609 Promotes Breast Cancer Cell Growth, Migration, and Invasion by Elevating p70S6K1 via Sponging miR-145-5p, Cancer Management and Research, 10, pp. 3881-3890, (2018)

[14]

Wu S., Lu J., Zhu H., Et al., A Novel Axis of circKIF4A-miR-637-STAT3 Promotes Brain Metastasis in Triple-Negative Breast Cancer, Cancer Letters, 581, (2024)

[15]

Li Y., Jiang B., He Z., Et al., circIQCH Sponges miR-145 to Promote Breast Cancer Progression by Upregulating DNMT3A Expression, Aging (Albany NY), 12, 15, pp. 15532-15545, (2020)

[16]

He L., Hannon G.J., MicroRNAs: Small RNAs With a Big Role in Gene Regulation, Nature Reviews Genetics, 5, 7, pp. 522-531, (2004)

[17]

Shi X.Y., Wang H., Wang W., Gu Y.H., MiR-98-5p Regulates Proliferation and Metastasis of MCF-7 Breast Cancer Cells by Targeting Gab2, European Review for Medical and Pharmacological Sciences, 24, 21, (2020)

[18]

Xiong X., Xu W., Gong J., Et al., miR-937-5p Targets SOX17 to Modulate Breast Cancer Cell Cycle and Cell Proliferation Through the Wnt Signaling Pathway, Cellular Signalling, 77, (2020)

[19]

Li Z., Zheng J., Lin W., Et al., Circular RNA hsa_circ_0001785 Inhibits the Proliferation, Migration and Invasion of Breast Cancer Cells In Vitro and In Vivo by Sponging miR-942 to Upregulate SOCS3, Cell Cycle, 19, 21, pp. 2811-2825, (2020)

[20]

Ai H., Zhou W., Wang Z., Qiong G., Chen Z., Deng S., microRNAs-107 Inhibited Autophagy, Proliferation, and Migration of Breast Cancer Cells by Targeting HMGB1, Journal of Cellular Biochemistry, 120, 5, pp. 8696-8705, (2018)

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