Synthesis of 1-[2-[18F]Fluoro-1-(hydroxymethyl)-ethoxy]methyl-2-nitroimidazole ([18F]FENI), a potential agent for imaging hypoxic tissues by PET

被引：0

作者：

Wada, Hiroaki ^{[1
]}

Iwata, Ren ^{[1
,2
]}

Ido, Tatsuo ^{[1
]}

Takai, Yoshihiro ^{[3
]}

机构：

[1] CYRIC Tohoku University, Sendai 980-8578, Japan

[2] Quant. Sci. and Energy Engineering, Tohoku University, Sendai 980-8579, Japan

[3] School of Medicine, Tohoku University, Sendai 980-8575, Japan

来源：

Journal of Labelled Compounds and Radiopharmaceuticals | 2000年 / 43卷 / 08期

关键词：

Fluorine; -; Tissue;

D O I：

10.1002/1099-1344(200007)43:83.0.CO;2-5

中图分类号：

学科分类号：

摘要：

Fluorine-18 labeled 1-[2-fluoro-1-(hydroxymethyl)ethoxy]-mehyl-2-nitroimidazole ([18F]FENI), a novel, potential radiotracer for imaging hypoxic tissue by PET, was synthesized. The [18F]FENI was prepared by nucleophilic 18F-fluorination of the precursor, 1-[2-(toluene-4-sulfoxy)-1-(acetoxymethyl)ethoxy]methyl-2-nitroimidazole, followed by deprotection and HPLC purification. Radiochemically pure [18F]FENI was obtained in overall yields of 3-11% (EOB) with specific activity of > 26 GBq/μmol (EOS) within 90 min.

引用

页码：785 / 793