Mobile phone positioning data with wide coverage provides very good data resources for the study of urban residents travel rules. According to the characteristics of mobile phone positioning data, propose a spatio-temporal clustering algorithm for mining stops of residents’ daily activities; on this basis, use Apriori algorithm for mining frequent travel path of the residents. Collecting 108 anonymous users’ mobile phone positioning data for up to seven months in a city for the test, results show that resident activity rules mining can be effectively carried out with the use of mobile phone positioning data. © Sila Science. All Rights Reserved.