2-Ferrocene-4-amine-1H-benzo[d]imidazole and their derivatives: Synthesis, biological and docking study

被引：0

作者：

Kawad, Mukesh ^{[1
,4
]}

Sangani, Sagar ^{[1
,4
]}

Parmar, Jigneshkumar ^{[1
]}

Dabhi, Ranjitsinh C. ^{[2
]}

Arya, Prashant S. ^{[3
]}

Teraiya, Nishith ^{[5
]}

Ahmed, Sarfaraz ^{[6
]}

Ameta, Rakesh Kumar ^{[1
,7
]}

机构：

[1] KSV Univ, Dept Chem, SMMPISR, Gandhinagar, Gujarat, India

[2] Gujarat Univ, Univ Sch Sci, Dept Chem, Ahmedabd 380009, Gujarat, India

[3] UPL Univ Sustainable Technol, SRICT Inst Sci & Res, Vataria 393135, Gujarat, India

[4] Piramal Pharm Solut, Plot 18, Ahmadabad, Gujarat, India

[5] Kadi Sarva Vishvavidhyalaya, KB Inst Pharmaceut Educ & Res, Dept Pharmaceut Chem, Gandhinagar 382023, Gujarat, India

[6] King Saud Univ, Coll Pharm, Dept Pharmacognosy, POB 2457, Riyadh 11451, Saudi Arabia

[7] Gandhinagar Univ, Gandhinagar Inst Sci, Dept Chem, Gandhinagar 382721, Gujarat, India

来源：

POLYHEDRON | 2024年 / 264卷

关键词：

Organometallic; 2-Ferrocene-4-amine-1H-benzo[d]imidazole; DNA binding; Docking; Cytotoxicity; Antimicrobial; FERROCENE; COMPLEXES; FERROCIPHENOLS;

D O I：

10.1016/j.poly.2024.117242

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

An organometallic series based on 2-ferrocene-4-amine-1H-benzo[d]imidazole derivative has been synthesized and characterized through FTIR, H/CNMR, and LCMS. Their antimicrobial activity was assessed by testing them against B. subtills, Staphylococcus aureus, E. faecalis, S. marcescens, E. coli, K. pneumoniae, C. albicans, A. niger, Mucor sp. where they showed good zone of inhibition (ZOI) as compared to standards. The cytotoxicity of synthesized compounds was tested against Hela (cervical) and MCF-7 (breast) cancer cell lines where compound 5a and 5b displayed equivalent potency to the standard while 5e demonstrated highest cytotoxicity against both cell lines. Their comparative docking analysis with DNA suggested that docking score of 5e was -7.4 kcal/mol versus -6 kcal/mol of ethidium bromide, indicating that our designed compound acts via DNA intercalation.

引用

页数：8

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