Hemostasis properties of silk fibroin materials under different types of hydrolysis

被引：0
|
作者：
Lei C. [1 ,2 ]
Yu L. [1 ]
Zhu H. [1 ,2 ]
Zheng T. [1 ]
Chen J. [1 ,2 ]
机构：
[1] College of Textile Science and Engineering(International Institute of Silk), Zhejiang Sci-Tech University, Hangzhou
[2] Zhejiang Provincial Key Laboratory of Fiber Materials and Manufacturing Technology, Hangzhou
来源：
Fangzhi Xuebao/Journal of Textile Research | 2022年 / 43卷 / 04期
关键词：
Enzyme hydrolysis; Hemostasis property; Salt hydrolysis; Silk; Silk fibroin; Types of hydrolysis;
D O I：
10.13475/j.fzxb.20210302305
中图分类号：
学科分类号：
摘要：
Aiming at the improvement of hemostasis properties of silk fibroin materials fabricated by salt hydrolysis and enzyme hydrolysis method, the silk fibroin materials were prepared via a freeze-drying method. The molecular weight, water solubility and hemostatic effect of the resultant material were analyzed by gel filtration chromatography, water solubility test, coagulation factor test, platelet adhesion test, enzyme-linked immunosorbent assay and rat liver injury model. The results showed that compared with the salt hydrolysis method, the enzyme hydrolysis method could endow a lower molecular weight and better water soluble, which is conducive to activating the coagulation factor XII to promote endogenous coagulation. Moreover, the platelet adhesion and platelet factor 4 content increase significantly, the amount of bleeding from the rat liver is reduced with shortened bleeding time, indicating better hemostatic effect than that of Yunnan white medicine. © 2022, Periodical Agency of Journal of Textile Research. All right reserved.
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页码：15 / 19
页数：4
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