Association of vitamin D receptor gene polymorphisms with calcium oxalate calculus disease

被引：0

作者：

Wang, Shaogang ^{[1
]}

Liu, Jihong ^{[1
]}

Hu, Shaoqun ^{[1
]}

Ye, Zhangqun ^{[1
]}

机构：

[1] Department of Urology, Huazhong University of Science and Technology, Tongji Hospital, Wuhan 430030

来源：

Journal of Huazhong University of Science and Technology - Medical Science | 2003年 / 23卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Calcium - Diseases - Frequencies - Genetic engineering - Patient treatment;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

To study the relationship between polymorphism of vitamin D receptor (VDR) allele with formation of calcium oxalate calculus and find the predisposing genes of calcium oxalate calculus, we screened out 150 patients who suffered from calcium oxalate calculus. 36 of them had idiopathic hypercalciuria according to analysis of calculus component and assay of urine calcium. The polymorphisms of VDR gene Taq1, Apa1 and Fok1 were detected using PCR-RFLP technique and the correlation were analyzed between the polymorphism and urinary calculus or between the polymorphism and hypercalciuria. The difference in each genotypic frequency of the allele of promoter Fok1 between calculus group and healthy group or between idiopathic hypercalciuria calculus group and health group was significant. The content of 24-h urine calcium of those who had genotype ff was obviously higher than that of those who have other genotypes in the same group. There was no significant difference in the polymorphism of gene Apa1 and Taq1 between each two groups. It is concluded that hypercalciuria and calcium oxalate calculus were related to the polymorphism of VDR gene's promoter Fok1 allele, but it had nothing to do with the polymorphism of gene Apa1 and Taq1. The genotype ff was a candidate heredity marker of calcium calculus disease.

引用

页码：38 / 41