Base-catalyzed selective esterification of alcohols with unactivated esters

被引：0
作者：
Zhang C. [1 ]
Zhang G. [1 ]
Luo S. [1 ]
Wang C. [1 ]
Li H. [1 ]
机构：
[1] Key Laboratory of Sensor Analysis of Tumor Marker, Ministry of Education, Shandong Key Laboratory of Biochemical Analysis, Key Laboratory of Analytical Chemistry for Life Science in Universities of Shandong, College of Chemistry and Molecular Engineering,
来源：
Organic and Biomolecular Chemistry | 2018年 / 16卷 / 44期
关键词：
This research was supported by the Shandong Provincial Natural Science Foundation of China (No. ZR2017MB029; ZR2017BB060); the Qingdao Source Innovation Program Foundation (18-2-2-49-jch) and the Qingdao University of Science and Technology Talent Startup Fund Foundation (No. 010022797; 010022846) for financial support;
D O I：
10.1039/C8OB02411A
中图分类号：
学科分类号：
摘要：
A practical and efficient base-catalyzed esterification has been developed for the facile synthesis of a broad range of esters from simple alcohols with unactivated tert-butyl esters. This protocol could be conducted at mild conditions, providing esters in high to excellent yields with good functional tolerance. Mechanistic studies provided evidence of an exchange of the tert-butyl alkoxide metal with the alcohol, producing a new alkoxide to participate in the transesterification reaction. © The Royal Society of Chemistry.
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页码：8467 / 8471
页数：4
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