Synthesis and Drug Releasing Effectiveness of Hollow Mesoporous Silica Nanospheres with Ordered Mesochannels

被引：0

作者：

Li S. ^{[1
]}

Ma N. ^{[2
]}

Zhang Y. ^{[3
]}

Liu W. ^{[1
]}

Zhang X. ^{[2
]}

Chen Z. ^{[1
]}

Fu J. ^{[1
]}

Huang Y. ^{[2
]}

Yang J. ^{[2
]}

机构：

[1] School of Mechatronic Engineering, North University of China, Taiyuan

[2] State Key Lab of New Ceramics and Fine Processing, School of Materials Science and Engineering, Tsinghua University, Beijing

[3] School of Material Science and Engineering, Dalian Jiaotong University, Dalian, 116021, Liaoning

来源：

Kuei Suan Jen Hsueh Pao/Journal of the Chinese Ceramic Society | 2017年 / 45卷 / 03期

关键词：

Drugreleasing; Hollow nanosphere; Mesoporous; Silica;

D O I：

10.14062/j.issn.0454-5648.2017.03.01

中图分类号：

学科分类号：

摘要：

The mesoporous silica solid spheres with different silica condensation degrees inside and outside were prepared via the hydrolysis and condensation of tetraethoxysilane (TEOS). The inner part of solid spheres is more easily dissolved rather than the outer part, and the inner part of the solid spheres is dissolved in deionized water at room temperature to obtain the hollow mesoporous silica nanospheres (HMSS) with ordered mesochannels. A facile method for preparing HMSS by water dissoving at room temperature was developed. The performance of HMSS in drug loading and releasing was investigated. The results show that this method can synthesize the HMSS with a well-defined spherical morphology, uniform particle size (i.e., 460 nm), high specific surface area (i.e., 1 237 m2/g) and ordered mesochannels (i.e., 2.7 nm), and the superior performance in drug releasing. The loading content of CPT-11 is 14.50%, and the drug releasing amount in 108 h at pH 7.2, 5.5 and 4.2 can reach 28.49%, 39.22% and 77.72%, respectively. © 2017, Editorial Department of Journal of the Chinese Ceramic Society. All right reserved.

引用

页码：327 / 332

页数：5

共 19 条

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