In situ gelling polysaccharide-based hydrogel for cell and drug delivery in tissue engineering

被引：0
|
作者：
20134917046890
机构：
[1] Cheng, Yixing
[2] 2,Nada, Ahmed A.
[3] Valmikinathan, Chandra M.
[4] Lee, Paul
[5] Liang, Danni
[6] Yu, Xiaojun
[7] 2,3,4,Kumbar, Sangamesh G.
来源：
Kumbar, S.G. (kumbar@uchc.edu) | 1600年 / John Wiley and Sons Inc卷 / 131期
关键词：
Injectable hydrogels have attracted a great deal of attention as cell carriers and bioactive agents in regenerative medicine due to their ability to fill complex three-dimensional (3D) tissue gaps and relative ease of in vivo administration. Polysaccharide-based hydrogels can provide microenvironments that favor tissue regeneration and biocompatibility due to their chemical similarities with native extracellular matrix components. This manuscript reports the in vitro application of an injectable chitosan-based polysaccharide hydrogel for cell and protein delivery. Crosslinked hydrogels were produced by the reaction between the amino functionality of chitosan and the aldehyde of dextran aldehyde resulting in an imine bond (Schiff's base) formation in aqueous solutions. This approach eliminated the use of additional crosslinking agents which may pose undesired side effects regarding cytotoxicity and biocompatibility. Additionally; we demonstrate versatility of the gel in terms of its fabrication; and ability to alter mechanical properties by changing the crosslinking extent due to aldehyde content. Bovine serum albumin (BSA); used as a model protein; followed a steady release pattern from the gel. BSA release was dependent on the extent of hydrogel crosslinking. Increase in crosslinking extent resulted in improved mechanical properties and sustained release of BSA. Human fetal osteoblasts encapsulated into the hydrogel showed at least 70% viability and continued to proliferate under in vitro culture. © 2013 Wiley Periodicals; Inc;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Journal article (JA)
引用
收藏
相关论文
共 50 条
  • [1] In Situ Gelling Polysaccharide-Based Hydrogel for Cell and Drug Delivery in Tissue Engineering
    Cheng, Yixing
    Nada, Ahmed A.
    Valmikinathan, Chandra M.
    Lee, Paul
    Liang, Danni
    Yu, Xiaojun
    Kumbar, Sangamesh G.
    JOURNAL OF APPLIED POLYMER SCIENCE, 2014, 131 (04)
  • [2] IN SITU GELLING POLYSACCHARIDE-BASED, DOUBLE NETWORK HYDROGEL FOR CARTILAGE REGENERATION THERAPIES
    Mihajlovic, Marko
    Rikkers, Margot
    Ilochonwu, Blessing
    Ito, Keita
    Vermonden, Tina
    TISSUE ENGINEERING PART A, 2022, 28 : S174 - S174
  • [3] Development of a Polysaccharide-Based Hydrogel Drug Delivery System (DDS): An Update
    Pushpamalar, Janarthanan
    Meganathan, Puviarasi
    Tan, Hui Li
    Dahlan, Nuraina Anisa
    Ooi, Li-Ting
    Neerooa, Bibi Noorheen Haleema Mooneerah
    Essa, Raahilah Zahir
    Shameli, Kamyar
    Teow, Sin-Yeang
    GELS, 2021, 7 (04)
  • [4] Polysaccharide-Based Transdermal Drug Delivery
    Li, Jingyuan
    Xiang, Hong
    Zhang, Qian
    Miao, Xiaoqing
    PHARMACEUTICALS, 2022, 15 (05)
  • [5] The in vivo degradation of a ruthenium labelled polysaccharide-based hydrogel for bone tissue engineering
    Laib, Samia
    Fellah, Borhane H.
    Fatimi, Ahmed
    Quillard, Sophie
    Vinatier, Claire
    Gauthier, Olivier
    Janvier, Pascal
    Petit, Marc
    Bujoli, Bruno
    Bohic, Sylvain
    Weiss, Pierre
    BIOMATERIALS, 2009, 30 (08) : 1568 - 1577
  • [6] Recent Progress of Polysaccharide-Based Hydrogel Interfaces for Wound Healing and Tissue Engineering
    Zhu, Tianxue
    Mao, Jiajun
    Cheng, Yan
    Liu, Haoran
    Lv, Lu
    Ge, Mingzheng
    Li, Shuhui
    Huang, Jianying
    Chen, Zhong
    Li, Huaqiong
    Yang, Lei
    Lai, Yuekun
    ADVANCED MATERIALS INTERFACES, 2019, 6 (17):
  • [7] New Formulations of Polysaccharide-Based Hydrogels for Drug Release and Tissue Engineering
    Camponeschi, Francesca
    Atrei, Andrea
    Rocchigiani, Giulia
    Mencuccini, Lorenzo
    Uva, Marianna
    Barbucci, Rolando
    GELS, 2015, 1 (01) : 3 - 23
  • [8] In situ gelling polyvalerolactone-based thermosensitive hydrogel for sustained drug delivery
    Mishra, Gyan P.
    Kinser, Reid
    Wierzbicki, Igor H.
    Alany, Raid G.
    Alani, Adam W. G.
    EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2014, 88 (02) : 397 - 405
  • [9] Polysaccharide-Based In Situ Self-Healing Hydrogels for Tissue Engineering Applications
    Maiz-Fernandez, Sheila
    Perez-Alvarez, Leyre
    Ruiz-Rubio, Leire
    Vilas-Vilela, Jose Luis
    Lanceros-Mendez, Senentxu
    POLYMERS, 2020, 12 (10) : 1 - 33
  • [10] A covalently crosslinked polysaccharide hydrogel for potential applications in drug delivery and tissue engineering
    Xingyi Li
    Yuhua Weng
    Xiangye Kong
    Binjun Zhang
    Mei Li
    Kai Diao
    Zhaoliang Zhang
    Xianhuo Wang
    Hao Chen
    Journal of Materials Science: Materials in Medicine, 2012, 23 : 2857 - 2865
12345