21. pH-sensitive chitosan-based nanoparticles for protein drug delivery: Oral approaches: Original Research Article: A novel pH-sensitive hydrogel composed of carboxymethyl chitosan and alginate cross-linked by genipin for protein drug delivery, 2004 References

[1] Chen S.C., Wu Y.C., Mi F.L., Lin Y.H., Yu L.C., Sung H.W., A novel pH-sensitive hydrogel composed of N, O-carboxymethyl chitosan and alginate cross-linked by genipin for protein drug delivery, J. Control. Release, 96, pp. 285-300, (2004)

[2] Sung H.W., Sonaje K., Liao Z.X., Hsu L.W., Chuang E.Y., PH-Responsive nanoparticles shelled with chitosan for oral delivery of insulin: From mechanism to therapeutic applications, Acc. Chem. Res., 45, pp. 619-629, (2012)

[3] Chen M.C., Sonaje K., Chen K.J., Sung H.W., A review of the prospects for polymeric nanoparticle platforms in oral insulin delivery, Biomaterials, 32, pp. 9826-9838, (2011)

[4] Sung H.W., Sonaje K., Feng S.S., Nanomedicine for diabetes treatment, Nanomedicine, 6, pp. 1297-1300, (2011)

[5] Hsu L.W., Ho Y.C., Chuang E.Y., Chen C.T., Juang J.H., Su F.Y., Hwang S.M., Sung H.W., Effects of pH on molecular mechanisms of chitosan-integrin interactions and resulting tight-junction disruptions, Biomaterials, 34, pp. 784-793, (2013)

[6] Chen M.C., Wong H.S., Lin K.J., Chen H.L., Wey S.P., Sonaje K., Lin Y.H., Chu C.Y., Sung H.W., The characteristics, biodistribution and bioavailability of a chitosan-based nanoparticulate system for the oral delivery of heparin, Biomaterials, 30, pp. 6629-6637, (2009)

[7] Sonaje K., Lin K.J., Wang J.J., Mi F.L., Chen C.T., Juang J.H., Sung H.W., Self-assembled pH-sensitive nanoparticles: A platform for oral delivery of protein drugs, Adv. Funct. Mater., 20, pp. 3695-3700, (2010)

[8] Nguyen H.N., Wey S.P., Juang J.H., Sonaje K., Ho Y.C., Chuang E.Y., Hsu C.W., Yen T.C., Lin K.J., Sung H.W., The glucose-lowering potential of exendin-4 orally delivered via a pH-sensitive nanoparticle vehicle and effects on subsequent insulin secretion in vivo, Biomaterials, 32, pp. 2673-2682, (2011)

[9] Chen M.C., Mi F.L., Liao Z.X., Hsiao C.W., Sonaje K., Chung M.F., Hsu L.W., Sung H.W., Recent advances in chitosan-based nanoparticles for oral delivery of macromolecules, Adv. Drug Deliv. Rev., 65, pp. 865-879, (2012)

[10] Chuang E.Y., Lin K.J., Su F.Y., Chen H.L., Maiti B., Ho Y.C., Yen T.C., Panda N., Sung H.W., Calcium depletion-mediated protease inhibition and apical-junctional- complex disassembly via an EGTA-conjugated carrier for oral insulin delivery, J. Control. Release, 169, pp. 296-305, (2012)

[1] Chen S.C., Wu Y.C., Mi F.L., Lin Y.H., Yu L.C., Sung H.W., A novel pH-sensitive hydrogel composed of N, O-carboxymethyl chitosan and alginate cross-linked by genipin for protein drug delivery, J. Control. Release, 96, pp. 285-300, (2004)

[2] Sung H.W., Sonaje K., Liao Z.X., Hsu L.W., Chuang E.Y., PH-Responsive nanoparticles shelled with chitosan for oral delivery of insulin: From mechanism to therapeutic applications, Acc. Chem. Res., 45, pp. 619-629, (2012)

[3] Chen M.C., Sonaje K., Chen K.J., Sung H.W., A review of the prospects for polymeric nanoparticle platforms in oral insulin delivery, Biomaterials, 32, pp. 9826-9838, (2011)

[4] Sung H.W., Sonaje K., Feng S.S., Nanomedicine for diabetes treatment, Nanomedicine, 6, pp. 1297-1300, (2011)

[5] Hsu L.W., Ho Y.C., Chuang E.Y., Chen C.T., Juang J.H., Su F.Y., Hwang S.M., Sung H.W., Effects of pH on molecular mechanisms of chitosan-integrin interactions and resulting tight-junction disruptions, Biomaterials, 34, pp. 784-793, (2013)

[6] Chen M.C., Wong H.S., Lin K.J., Chen H.L., Wey S.P., Sonaje K., Lin Y.H., Chu C.Y., Sung H.W., The characteristics, biodistribution and bioavailability of a chitosan-based nanoparticulate system for the oral delivery of heparin, Biomaterials, 30, pp. 6629-6637, (2009)

[7] Sonaje K., Lin K.J., Wang J.J., Mi F.L., Chen C.T., Juang J.H., Sung H.W., Self-assembled pH-sensitive nanoparticles: A platform for oral delivery of protein drugs, Adv. Funct. Mater., 20, pp. 3695-3700, (2010)

[8] Nguyen H.N., Wey S.P., Juang J.H., Sonaje K., Ho Y.C., Chuang E.Y., Hsu C.W., Yen T.C., Lin K.J., Sung H.W., The glucose-lowering potential of exendin-4 orally delivered via a pH-sensitive nanoparticle vehicle and effects on subsequent insulin secretion in vivo, Biomaterials, 32, pp. 2673-2682, (2011)

[9] Chen M.C., Mi F.L., Liao Z.X., Hsiao C.W., Sonaje K., Chung M.F., Hsu L.W., Sung H.W., Recent advances in chitosan-based nanoparticles for oral delivery of macromolecules, Adv. Drug Deliv. Rev., 65, pp. 865-879, (2012)

[10] Chuang E.Y., Lin K.J., Su F.Y., Chen H.L., Maiti B., Ho Y.C., Yen T.C., Panda N., Sung H.W., Calcium depletion-mediated protease inhibition and apical-junctional- complex disassembly via an EGTA-conjugated carrier for oral insulin delivery, J. Control. Release, 169, pp. 296-305, (2012)