Synthesis and antitumor activity of amino acid derivatives containing phosphonate backbones

被引：0

作者：

Yang, Jia-Qiang ^{[1
]}

Yang, Xuan ^{[2
]}

Zhang, De-Hua ^{[1
]}

Deng, Cong-Ling ^{[1
]}

Chen, Lei ^{[1
]}

机构：

[1] School of Pharmacy, Zunyi Medical College, Zunyi,Guizhou,563003, China

[2] Chemistry Department, University of Manitoba, Winnipeg,MB,R3T4K6, Canada

来源：

Jingxi Huagong/Fine Chemicals | 2016年 / 33卷 / 05期

关键词：

Cell culture;

D O I：

10.13550/j.jxhg.2016.05.015

中图分类号：

O62 [有机化学]; TQ [化学工业];

学科分类号：

070303 ; 0817 ; 081704 ;

摘要：

In search of more effective anticancer agents, according to the combination principle, 9 phosphonate derivatives were designed and synthesized. The structures were clearly established by elemental analysis, IR, 1HNMR and 13CNMR, and their antiproliferative activities were evaluated against some tumor cell lines by using a methylthiazolyldiphenyl-tetrazolium bromide(MTT)method. Preliminary results in bioactivity tests indicated that they exhibited certain antitumor activities. Among the active compounds, compounds IIIf, IIIi had better inhibition effect on cells growth, espectively, compounds IIIi showed remarkable activities against A-549, SGC-7901 and EC-109 with IC50 values of (7.0±0.8), (6.9±0.8) and (7.3±0.7) μmol/L respectively, similar to cisplatin, which were worth further investigation. © 2016, Editorial Office of FINE CHEMICALS. All right reserved.

引用

页码：564 / 567