The use of gold nanoparticle aggregation for DNA computing and logic-based biomolecular detection

被引：0

作者：

Lee, In-Hee ^{[1
]}

Yang, Kyung-Ae ^{[1
,2
]}

Lee, Ji-Hoon ^{[2
]}

Park, Ji-Yoon ^{[3
]}

Chai, Young Gyu ^{[3
]}

Lee, Jae-Hoon ^{[4
,5
]}

Zhang, Byoung-Tak ^{[1
,2
]}

机构：

[1] School of Computer Science and Engineering, Seoul National University, Seoul 151-742, 599 Gwanak-ro, Gwanak-gu

[2] Center for Bioinformation Technology, Seoul National University, Seoul 151-742, 599 Gwanak-ro, Gwanak-gu

[3] Division of Molecular and Life Sciences, Hanyang University, Ansan, Gyeonggi-do 426-791, 1271 Sa-dong, Sangnok-gu

[4] Fachgebiet Mikrobiologie und Genetik, Institut für Biotechnologie, Technische Universität Berlin, D-13355 Berlin

[5] Digital Genomics, Seoul 153-782, Namsung Plaza, 345-40 Gasan-dong, Geumcheon-gu

来源：

| 2008年 / Institute of Physics Publishing卷 / 19期

关键词：

Biomolecules - Calculations - Metal nanoparticles - Gold nanoparticles - Visualization - Computer circuits - Computation theory;

D O I：

10.1088/0957-4484/19/39/395103

中图分类号：

学科分类号：

摘要：

The use of DNA molecules as a physical computational material has attracted much interest, especially in the area of DNA computing. DNAs are also useful for logical control and analysis of biological systems if efficient visualization methods are available. Here we present a quick and simple visualization technique that displays the results of the DNA computing process based on a colorimetric change induced by gold nanoparticle aggregation, and we apply it to the logic-based detection of biomolecules. Our results demonstrate its effectiveness in both DNA-based logical computation and logic-based biomolecular detection. © IOP Publishing Ltd.

引用

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