Hyaluronic acid modified prussian blue analogs/TiO2 janus nanostructures through efficient charge separation to enhance photocatalytic-driven dual gas for achieve multimodal treatment of rheumatoid arthritis

被引:1
作者
Chao, Minghao [1 ,2 ,4 ,5 ]
Hua, Zhiyuan [1 ,2 ]
Zhu, Jun [3 ]
Wu, Guoquan [1 ,2 ]
Fan, Liying [1 ,2 ]
Tang, Rongze [1 ,2 ]
Chen, Hongliang [1 ]
Gao, Fenglei [2 ]
机构
[1] Xuzhou Med Univ, Dept Orthoped, Affiliated Hosp, Xuzhou 221002, Jiangsu, Peoples R China
[2] Xuzhou Med Univ, Jiangsu Key Lab New Drug Res & Clin Pharm, Xuzhou 221004, Jiangsu, Peoples R China
[3] Xuzhou Med Univ, Peoples Hosp Huaian 2, Dept Orthoped, Affiliated Huaian Hosp, Huaian 223002, Peoples R China
[4] Wenzhou Med Univ, Dept Orthopaed Surg, Lishui Cent Hosp, Lishui 323000, Zhejiang, Peoples R China
[5] Wenzhou Med Univ, Affiliated Hosp 5, Lishui 323000, Zhejiang, Peoples R China
关键词
Janus nanoparticles; Anti-oxidative stress; Photocatalysis; HYDROGEN; THERAPY; OXYGEN;
D O I
10.1016/j.ijbiomac.2024.136567
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by the abnormal proliferation of fibroblast-like synoviocytes and changes in the joint synovium, including elevated reactive oxygen species, decreased pH, and reduced oxygen content. In this study, we synthesized a novel nanocomposite material, namely HA-PBA-TiO2 Janus nanocomposite, by in situ etching in prussian blue analogs doped with Co and Ni, followed by the growth of TiO2 nano-flowers and encapsulation in hyaluronic acid. When these janus nanoparticles diffused to the inflammatory sites of RA, they exhibited outstanding photocatalytic water-splitting ability under 660 nm laser irradiation, generating H2 and O2. This capability helps ameliorate the hypoxic microenvironment at RA inflammatory sites by eliminating reactive oxygen species (ROS) and enhancing antioxidation and oxygenation. Furthermore, owing to the doping of Co and Ni, HA-PBA-TiO2 exhibits photothermal conversion capability, which significant damage to FLS upon exposure to 660 nm laser irradiation, thereby controlling their aberrant proliferation. Through a series of in vitro and in vivo experiments, we validated the significant therapeutic efficacy of HA-PBA-TiO2 in treating RA, highlighting its broad prospects for application.
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页数:10
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