Evaluation of selective positron emission tomography template method for spatial normalization of amyloid imaging with 11 C-pittsburgh compound B

被引:5
作者
Departments of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, Seoul [1 ]
138-736, Korea, Republic of
不详 [2 ]
不详 [3 ]
机构
[1] Departments of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, Seoul
[2] Departments of Neurology, Asan Medical Center, University of Ulsan College of Medicine
[3] Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul
来源
J. Comput. Assisted Tomogr. | / 6卷 / 924-929期
关键词
Alzheimer disease; amyloid; spatial normalization; template;
D O I
10.1097/RCT.0000000000000123
中图分类号
学科分类号
摘要
Objective: Spatial normalization of 11C-Pittsburgh Compound B (PiB) images is challenging for an automatic quantitative analysis without magnetic resonance imaging (MRI) because of different distribution patterns between amyloid positive and negative images. To overcome this issue, we evaluated a selective positron emission tomography template (SPT) method.; Materials and Methods: Three sets of single positron emission tomography templates were created: PiB negative template, PiB positive template, and mixed template. Sixty-one patients with dementia were enrolled as the validation cohort.Magnetic resonance imaging-aided normalization method was used as a reference. The SPT method was based on visual classification (positive, negative, and equivocal). The optimal templates for each visual group were determined by correlation values and average percent errors (APEs) with MRI-aided normalization. The results of the SPT and the single template methods were compared with those of MRI-aided normalization in terms of correlation values, APEs, and concordance rates.; Results: The SPT (PiB negative template for the negative and equivocal groups and PiB positive template for the positive group) showed higher correlations and concordance rate and lower APEs with MRI-aided normalization than did the single template.; Conclusions: Use of the SPT provides accurate normalization of amyloid images without MRI. © 2014 Lippincott Williams & Wilkins.
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页码:924 / 929
页数:5
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