Antimonene Nanoflakes as a Photoacoustic Imaging Contrast Agent for Tumor in vivo Imaging

被引:0
作者
Yu J. [1 ]
Wang X. [1 ]
Feng J. [2 ]
Zhang N. [2 ]
Wang P. [1 ]
机构
[1] Beijing Engineering Research Center of Laser Technology, Institute of Laser Engineering of Beijing University of Technology, Key Laboratory of Trans-Scale Laser Manufacturing Technology, Beijing
[2] College of Electronic Information and Control Engineering, Beijing University of Technology, Beijing
来源
Zhongguo Jiguang/Chinese Journal of Lasers | 2020年 / 47卷 / 02期
关键词
Biological optics; Contrast agent; Photoacoustic imaging; Tumor imaging; Two-dimensional materials;
D O I
10.3788/CJL202047.0207033
中图分类号
学科分类号
摘要
Photoacoustic imaging, a novel biomedical imaging technique that combines the advantages of optical imaging and acoustic imaging, offers high-resolution biological tissue imaging to facilitate the observation of deeper imaging sites. In other words, it breaks the "soft limit" of conventional optical bioimaging techniques. However, many diseases, especially in the early stage, present no obvious photoacoustic contrast; therefore, it is crucial to identify effective exogenous photoacoustic contrast agents. Here we introduce a novel two-dimensional material, antimonene nanoflakes (AMNFs), which demonstrates great optical absorption from 300 nm to 900 nm as well as excellent photothermal conversion efficiency and photoacoustic performance. This material is expected to be useful as a contrast agent, helping to achieve excellent photoacoustic imaging of ultra-small tumors in vivo. © 2020, Chinese Lasers Press. All right reserved.
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  • [1] Hahn M.A., Singh A.K., Sharma P., Et al., Nanoparticles as contrast agents for in-vivo bioimaging: current status and future perspectives, Analytical and Bioanalytical Chemistry, 399, 1, pp. 3-27, (2011)
  • [2] Michalet X., Pinaud F.F., Bentolila L.A., Et al., Quantum dots for live cells, in vivo imaging, and diagnostics, Science, 307, 5709, pp. 538-544, (2005)
  • [3] Freudiger C.W., Min W., Saar B.G., Et al., Label-free biomedical imaging with high sensitivity by stimulated Raman scattering microscopy, Science, 322, 5909, pp. 1857-1861, (2008)
  • [4] Hong G.S., Antaris A.L., Dai H.J., Near-infrared fluorophores for biomedical imaging, Nature Biomedical Engineering, 1, (2017)
  • [5] Hyun H., Owens E.A., Wada H., Et al., Cartilage-specific near-infrared fluorophores for biomedical imaging, Angewandte Chemie International Edition, 54, 30, pp. 8648-8652, (2015)
  • [6] Hyun H., Wada H., Bao K., Et al., Phosphonated near-infrared fluorophores for biomedical imaging of bone, Angewandte Chemie International Edition, 53, 40, pp. 10668-10672, (2014)
  • [7] Giljohann D.A., Seferos D.S., Daniel W.L., Et al., Gold nanoparticles for biology and medicine, Angewandte Chemie International Edition, 49, 19, pp. 3280-3294, (2010)
  • [8] Gupta A.K., Gupta M., Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications, Biomaterials, 26, 18, pp. 3995-4021, (2005)
  • [9] Roca G., Costo R., Rebolledo F., Et al., Progress in the preparation of magnetic nanoparticles for applications in biomedicine, Journal of Physics D: Applied Physics, 42, 22, (2009)
  • [10] Hell S.W., Wichmann J., Breaking the diffraction resolution limit by stimulated emission: stimulated-emission-depletion fluorescence microscopy, Optics Letters, 19, 11, pp. 780-782, (1994)