Fabrication of porous poly (L-lactic acid) porous microspheres and its controlled drug release property

被引：0
|
作者：
Hu J. [1 ,2 ]
Liu R. [2 ]
Lao R. [2 ]
Zhao J. [2 ]
Wu D. [1 ]
机构：
[1] College of Resources Environmental and Chemical Engineering, Nanchang University, Nanchang
[2] College of Ecological and Resource Engineering, Wuyi University, Wuyishan
来源：
Wu, Daishe (daishewu@yahoo.com.cn) | 1600年 / Sichuan University卷 / 32期
关键词：
Controlled-releasing; Poly (L-lactic acid); Porous microspheres; Thermally induced phase separation;
D O I：
10.16865/j.cnki.1000-7555.2016.05.028
中图分类号：
学科分类号：
摘要：
Through dispersing the poly (L-lactic acid) (PLLA)/tetrahydrofuran (THF) solution in glycerol, a series of PLLA porous microspheres composed of sheave-like nanofibers were fabricated through a method which combines the self-emulsification with thermally induced phase separation (TIPS). Various structures and morphologies of the microspheres were fabricated by controlling PLLA concentration, solvent, mass ratio of (PLLA/THF) : glycerol, and the quenching method. The results indicate that the microspheres with regular shapes are synthesized when the mass fraction is 2%~5%, the m (PLLA/THF):m (glycerol) is 1:3 and quenching at -20℃ and -196℃. The porosity and the specific surface area of the microspheres can reach 95.44% and 32.53 m2/g, respectively. The load capacity of PLLA microspheres for bovine serum albumin (BSA) is 0.355 mg/mg and the drug releasing rate within 30 h is 59.8%, which reflect that this kind of microspheres is a great drug carrier for sustaining release. © 2016, Chengdu University of Science and Technology. All right reserved.
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页码：144 / 150and155
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