Preparation and characterisation of poly vinyl alcohol/hydroxyapatite nanocomposite via in situ synthesis: A potential material as bone tissue engineering scaffolds

被引：0

作者：

Poursamar S.A. ^{[1
]}

Orang F. ^{[1
]}

Bonakdar S. ^{[1
]}

Savar M.K. ^{[1
]}

机构：

[1] Biomedical Engineering Faculty, Amirkabir University of Technology, Tehran

来源：

International Journal of Nanomanufacturing | 2010年 / 5卷 / 3-4期

关键词：

Bone scaffold; HA; Hydroxyapatite; Poly vinyl alcohol; PVA;

D O I：

10.1504/IJNM.2010.033875

中图分类号：

学科分类号：

摘要：

Nanocomposite (NC) comprising poly vinyl alcohol (PVA), hydroxyapatite (HA) was synthesised using in situ mineralisation of HA within PVA aqueous solution. Freeze/thaw physical cross-linking along with both freeze/dry and particulate leaching methods were used to prepare porous polymeric matrix. TEM imaging ratifies formation of HA nanoparticles while FTIR analysis revealed the formation of chemical bounds among hydroxyl functional groups of PVA chains and hydroxyapatite structure. Mechanical tests were benefited to evaluate mechanical properties of the samples. Copyright © 2010 Inderscience Enterprises Ltd.

引用

页码：330 / 334

页数：4

共 7 条

[1]

Blout E.R., Karplus R., The infrared spectrum of polyvinyl alcohol, J. Am. Chem. Soc., 70, pp. 862-864, (1948)

[2]

Hassan C.M., Peppas N.A., Structure and applications of poly (vinyl alcohol) hydrogels produced by conventional crosslinking or by freezing/thawing methods, Advances in Polymer. Science, 153, pp. 37-64, (2000)

[3]

Kokubo T., Im H.M., Kawashita M., Novel bioactive materials with different mechanical properties, Biomaterials, 24, pp. 2161-2175, (2003)

[4]

Morales J.G., Burgues J.T., Boix T., Fraile J., Clemente R.R., Precipitation of stoichiometric hydroxyapatite by a continuous method, Cryst. Res. Technol., 36, (2001)

[5]

Murugan R., Ramakrishna S., Development of nanocomposites for bone grafting, Composites Science and Technology, 65, pp. 2385-2406, (2005)

[6]

Peppas N.A., Simmons R.E.P., Mechanistic analysis of protein delivery from porous poly (vinyl alcohol) systems, J. Drug Del. Sci. Tech., 14, pp. 285-289, (2004)

[7]

Peppas N.A., Stauffer S.R., Reinforced uncrosslinked poly (vinyl alcohol) gels produced by cyclic freezing thawing processes: A short review, J. Controlled Release, 16, pp. 305-310, (1991)

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