DNA nanostructures for stimuli-responsive drug delivery

被引：0
作者：
Wang T. [1 ]
Liu Y. [2 ]
Wu Q. [1 ]
Lou B. [1 ]
Liu Z. [1 ,3 ]
机构：
[1] Department of Pharmaceutics, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, 410013, Hunan Province
[2] Department of Pharmaceutical Engineering, College of Chemistry and Chemical Engineering, Central South University, Changsha, 410083, Hunan Province
[3] Molecular Imaging Research Center of Central South University, Changsha, 410008, Hunan
来源：
Smart Materials in Medicine | 2022年 / 3卷
基金：
中国国家自然科学基金;
关键词：
DNA nanostructure; Drug delivery systems; Responsive mechanisms; Stimuli-responsive;
D O I：
10.1016/j.smaim.2021.12.003
中图分类号：
学科分类号：
摘要：
DNA molecules have shown potential for drug delivery owing to their predictability and programmability. Due to the continuous development of DNA nanotechnology and the unique properties of DNA nanomaterials, many drug delivery systems based on stimuli-responsive DNA nanostructures have emerged. DNA nanostructures can be used as intelligent drug delivery vehicles to perform complex tasks, such as selectively deliver loads to targeted sites, and trigger the release of loads in response to stimuli. Herein, we systematically reviewed the recent studies on various stimuli-responsive DNA nanostructure based drug delivery systems and classified them according to different types of stimuli. Designing strategies and drug release behaviors were discussed. In the end, current challenges and prospects regarding this promising field were highlighted. © 2021
引用
收藏
页码：66 / 84
页数：18
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