Synthetic studies on the pederin family of antitumour agents. Syntheses of mycalamide B, theopederin D and pederin

被引：0

作者：

Kocienski, Philip ^{[1
]}

Narquizian, Robert ^{[1
]}

Raubo, Piotr ^{[1
]}

Smith, Christopher ^{[1
]}

Farrugia, Louis J. ^{[1
]}

Muir, Kenneth ^{[1
]}

Boyle, F. Thomas ^{[1
]}

机构：

[1] Department of Chemistry, Glasgow University, Glasgow, G12 8QQ, United Kingdom

来源：

Journal of the Chemical Society, Perkin Transactions 1 | 2000年 / 15期

关键词：

Crystalline materials - Nuclear magnetic resonance spectroscopy - Stereochemistry - Synthesis (chemical) - Tumors - X ray crystallography;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

The synthesis of mycalamide B, theopederin D and pederin, which are antitumour agents was discussed. All three compounds were prepared from 6-lithio-2,3-dimethyl-4-phenylselenomethyl-3,4-dihydro-2H-pyran and 2-(3-chloropropyl)-3,3-dimethyl-3,4-dihydro-2H-pyran-4-one. Ground state conformational models were proposed to explain the stereoselectivity of the reactions. The absolute and relative stereochemistry of the compounds has been established by X-ray crystallography and NMR studies.

引用

页码：2357 / 2384