Laser ablation-enhanced transdermal drug delivery

被引：0
作者：
机构：
[1] Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, RI 02881
来源：
Lu, W. (weilu@uri.edu) | 1600年 / Walter de Gruyter GmbH卷 / 02期
关键词：
Drug delivery; Laser ablation; Microporation; Nanoparticle; Transdermal;
D O I：
10.1515/plm-2013-0028
中图分类号：
学科分类号：
摘要：
Transdermal delivery offers an excellent route for drug and vaccine administration. Nonetheless, the lipid-rich outer stratum corneum layer of the skin presents a critical challenge to drug penetration. Laser ablation perforates epidermis through selective photothermolysis, making skin more permeable to hydrophilic and macromolecular drugs such as peptides, proteins, and genes. This review summarizes recent applications to laser ablation-enhanced transdermal delivery. Needle- and pain-free transcutaneous drug delivery via laser ablation provides an alternative approach to achieve local or systemic therapeutics. © 2013 Walter de Gruyter GmbH, Berlin/Boston.
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页码：315 / 322
页数：7
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