Electrochemical preparation and characterization of chitosan-coated superparamagnetic iron oxide (Fe3O4) nanoparticles

被引：14

作者：

Karimzadeh I. ^{[1
,2
]}

Aghazadeh M. ^{[3
]}

Doroudi T. ^{[1
]}

Ganjali M.R. ^{[4
]}

Kolivand P.H. ^{[1
]}

机构：

[1] Shefa Neuroscience Research Center, Khatam ol Anbia Hospital, Tehran

[2] Faculty of Science, Department of Physics, Central Tehran Branch, Islamic Azad University, Tehran

[3] Materials and Nuclear Research School, Nuclear Science and Technology Research Institute (NSTRI), Tehran

[4] Faculty of Chemistry, Center of Excellence in Electrochemistry, University of Tehran, Tehran

来源：

Aghazadeh, Mustafa (maghazadeh@aeoi.org.ir) | 2018年 / Taylor and Francis Ltd.卷 / 22期

关键词：

biomedical applications; cathodic electrosynthesis; chitosan; iron oxide nanoparticles; Nanomaterials;

D O I：

10.1080/14328917.2017.1323991

中图分类号：

学科分类号：

摘要：

In this work, a novel and one-step synthesis protocol is proposed to prepare naked and chitosan (CS) coated magnetite nanoparticles (MNPs). Well-defined Fe3O4 nanoparticles were prepared through cathodic electrochemical deposition (CED) under the mild conditions. The crystalline and completely spherical nanoparticles of naked Fe3O4 with uniform size of 8nm were electrodeposited from mixed iron chloride/nitrate aqueous solution by applying current density of 10 mA cm–2 for 30 min. The uniform chitosan coated MNPs with size of 10 nm were also prepared from 0.005M [FeCl2+Fe(NO3)3] + 1 g/L chitosan aqueous solution with only applying 10 mA cm–2 for 30 min. The prepared naked and chitosan coated MNPs were characterized through XRD, IR, FE-SEM, TEM,DSC-TGA, DLS and VSM techniques. The chitosan layer of the surface of MNPs was confirmed by FT-IR, DLS and DSC-TG analyses. The magnetic analysis via VSM revealed that both synthesized NPs exhibit excellent superparamagnetic behavior and can be used for a wide range of biomedical applications. The CS coated MNPs have negligible remnant magnetization (Mr = 0.26 emu g–1) and coercivity (C e = 0.5 Oe) as compared with those of naked NPs (Mr≈0.75 emu g–1 and C e≈2.3 Oe). In final, the possible mechanism of the Fe3O4 deposition on cathode surface was proposed and discussed in details. Bas on the obtained results, the CED strategy is introduced as an easy, fast and efficient preparation route of uniform MNPs with proper phase, size and magnetic characters for biomedical applications. © 2017, © 2017 Informa UK Limited, trading as Taylor & Francis Group.

引用

页码：352 / 360

页数：8

共 49 条

[1]

Arami H., Khandhar A., Liggitt D., Et al., In vivo delivery, pharmacokinetics, biodistribution and toxicity of iron oxide nanoparticles, Chem Soc Rev, 44, pp. 8576-8607, (2015)

[2]

Lu A.H., Salabas E.L., Schuth F., Magnetic nanoparticles: synthesis, protection, functionalization, and application, Angew Chem Int Ed, 46, pp. 1222-1244, (2007)

[3]

Revia R.A., Zhang M., Magnetite nanoparticles for cancer diagnosis, treatment, and treatment monitoring: recent advances, Mater Today, 19, pp. 157-168, (2016)

[4]

Kandasamy G., Maity D., Recent advances in superparamagnetic iron oxide nanoparticles (SPIONs) for in vitro and in vivo cancer nanotheranostics, Int J Pharm, 496, pp. 191-218, (2015)

[5]

Durr S., Janko C., Lyer S., Et al., Magnetic nanoparticles for cancer therapy, Nanotechnol Rev, 2, pp. 395-409, (2013)

[6]

Lee N., Yoo D., Ling D., Et al., Iron oxide based nanoparticles for multimodal imaging and magnetoresponsive therapy, Chem Rev, 115, pp. 10637-10689, (2015)

[7]

Icart L.P., dos Santos E.R.F., Pereira E.D., Et al., PLA-b-PEG/magnetite hyperthermic agent prepared by Ugi four component condensation, Express Polym Lett, 10, pp. 188-203, (2016)

[8]

Arsalani N., Fattahi H., Nazarpoor M., Synthesis and characterization of PVP-functionalized superparamagnetic Fe3O4 nanoparticles as an MRI contrast agent, Express Polym Lett, 4, pp. 329-338, (2010)

[9]

Zhong W., Liu P., Shi H.G., Et al., Ferroferric oxide/polystyrene (Fe3O4/PS) superparamagnetic nanocomposite via facile in situ bulk radical polymerization, Express Polym Lett, 4, pp. 183-187, (2010)

[10]

Qi H., Yan B., Lu W., Et al., A non-alkoxide sol–gel method for the preparation of magnetite (Fe3O4) nanoparticles, Current Nanosci, 7, pp. 381-388, (2011)

← 1 2 3 4 5 →