Development of bioactive organic-inorganic hybrid based on starch

被引：0

作者：

Miyazaki, Toshiki ^{[1
]}

Yasunaga, Shouji ^{[1
]}

Ishida, Eiichi ^{[2
]}

Ashizuka, Masahiro ^{[1
]}

Ohtsuki, Chikara ^{[3
]}

机构：

[1] Graduate School of Life Science and Systems Engineering, Kyushu Institute of Technology, Wakamatsu-ku, Kitakyushu 808-0196

[2] Faculty of Engineering, Kyushu Institute of Technology, Tobata-ku, Kitakyushu 804-8550

[3] Graduate School of Materials Science, Nara Institute of Science and Technology, Ikoma 630-0192

来源：

| 2005年 / Funtai Funamtsu Yakin Kyokai/Japan Soc. of Powder Metallurgy卷 / 52期

关键词：

Apatite; Bioactivity; Organic-inorganic hybrid; Simulated body fluid (SBF); Starch;

D O I：

10.2497/jjspm.52.360

中图分类号：

学科分类号：

摘要：

So-called bioactive ceramics have attractive features such as direct bone-bonding in living body. They are clinically utilized as important bone substitutes. However, their Young's modulus is much higher than that of natural bone. Previous studies reported that the essential condition for materials to show bone-bonding property, i.e. bioactivity, is formation of bone-like apatite on their surfaces after exposure to the body fluid. The same type of apatite formation can be observed even in a simulated body fluid (SBF) with inorganic ion concentrations similar to those of human extracellular fluid. Formation of the surface apatite can be induced both by dissolution of calcium ion (Ca 2+) and by silanol (Si-OH) group formed on the surfaces of materials. On the basis of these findings, organic modification of these components would produce bioactive materials with high flexibility. In the present study, we synthesized organic-inorganic hybrids from starch by chemical modification using glycidoxypropyltrimethoxysilane (GPS) and calcium chloride (CaCl2). Acceptance of the apatite formation of the hybrids was examined in SBF. The hybrids formed apatite in SBF within 7 d, even if molar ratio of CaCl 2 to GPS was reduced up to 0.01.

引用

页码：360 / 363

页数：3

共 15 条

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