For exploring the influence of different percentage walls with opening of first layer in different model, the seismic anti-collapse fragility analysis from single walls, interlayer walls and the entire structure were completed gradually. Based on reliable parameters for numerical simulation verified by test results, the load-displacement curves, that is, P-Δ curves of single walls were obtained by the finite element method software ABAQUS firstly. The interlayer restoring force models and simplified trilinear models were gotten by the overlaying and fitting curves of each floor secondly. Finally, the simplified trilinear model and 50% of incremental dynamic analysis (IDA) curves were used to obtain fragility analysis of different walls with opening in different models. The results show that with the increase of the wall percentage of first layer, the structural performance is decreased, at the same time, the peak ground acceleration and maximum story drift ratio are smaller at the same performance points. The structure meets the need of seismic precautionary standards when the percentage of opening wall is less than 50% and in less than 9.0 degree of seismic precautionary area. In order to ensure the good structural seismic performance, it is necessary to limit the percentage or quantity of walls with opening strictly. © 2017, Editorial Board of Journal of Huazhong University of Science and Technology. All right reserved.