Scanning surface plasmon resonance biosensor for array sample detection

被引：1
|
作者：
Qi, Pan [1 ,2 ]
Li, Ying [3 ]
Feng, Ming-Chuang [1 ,3 ]
Zhong, Jin-Gang [1 ,3 ]
机构：
[1] Department of Optoelectronic Engineering, Jinan University
[2] Department of Electronic Engineering, Guangdong Communication Polytechnic Institute
[3] Lab. of Optoelectronic Information and Sensing Technologies of Guangdong Higher Education Institute, Jinan University
来源：
Guangxue Jingmi Gongcheng/Optics and Precision Engineering | 2012年 / 20卷 / 11期
关键词：
Array scanning; Biosensor; Sample density; Surface plasmon resonance;
D O I：
10.3788/OPE.20122011.2365
中图分类号：
学科分类号：
摘要：
An scanning surface plasmon resonance biosensor was constructed to quantitatively detect array samples. First, based on the optimal rotation position in plane prism-coupling mode and a double-prism detection optical path, the scanning surface plasmon resonance biosensor for array samples was constructed. Then, the sample density of array samples was calculated. Finally, by taking the distilled water and glucose solution with different concentrations in 5, 10, 15, 20, 25, 30 and 35 mg/mL as array samples to be measured, the multi-sample spots were detected by surface plasmon resonance method. Experimental results show that the resonance angles of array samples are 73.745, 73.919, 74.052, 74.185, 74.306, 74.408, 74.549 and 74.660°, respectively, and the solution concentrations and their resonance angles show a good linear relation, which proves that the proposed method and device are feasibility. The device is significant for increasing the sample density of array samples and realizing the high precision detection.
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页码：2365 / 2372
页数：7
相关论文
共 10 条
  • [1] Schasfoort R.B.M., Tudos A.J., Handbook of Surface Plasmon Resonance, (2008)
  • [2] Kabashin A.V., Nikitin P.I., Surface plasmon resonance in-terferometer for bio-and chemical-sensors, Optics Communications, 150, 1-6, pp. 5-8, (1998)
  • [3] Mullett W.M., Lai E.P.C., Yeung J.M., Surface plasmon resonance-based immunoassays, Methods, 22, 1, pp. 77-91, (2000)
  • [4] Myszka D.G., Rich R.L., Implementing surface plasmon resonance biosensors in drug discovery, Pharmaceutical Science & Technology Today, 3, 9, pp. 310-317, (2003)
  • [5] Homola J., Lu H.B., Yee S.S., Dual-channel surface plasmon resonance sensor with spectral discrimination of sensing channels using dielectric overlayer, Electronics Letters, 35, 13, pp. 1105-1106, (1999)
  • [6] Nelson B.P., Grimsrud T.E., Liles M.R., Et al., Surface plasmon resonance imaging measurements of DNA and RNA hybridization adsorption onto DNA microarrays, Analytical Chemistry, 73, 1, pp. 1-7, (2001)
  • [7] Yuk J.S., Kim H.S., Jung J.W., Et al., Analysis of protein interactions on protein arrays by a novel spectral surface plasmon resonance imaging, Biosensors and Bioelectronics, 21, pp. 1521-1528, (2006)
  • [8] Qi P., Li Y., Zhong J.G., Optimized angle scanning method for array sample detection in surface plasmon resonance biosensor, Applied Optics, 51, 9, pp. 1245-1250, (2012)
  • [9] Yeh L.Y., Real-time measurement of glucose concentration and average refractive index using a laser interferometer, Opt. Lasers in Eng., 46, 9, pp. 666-670, (2008)
  • [10] Liu C., Zou Z.F., Chen S.F., Et al., Surface plasmon resonance sensor based on compact disk grating, Chinese Journal of Lasers, 39, 3, (2012)
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