Compact optical-resolution photoacoustic microscopy system based on a pulsed laser diode

被引:0
作者
Zeng, Lüming [1 ]
Liu, Guodong [1 ]
Yang, Diwu [2 ]
Ji, Xuanrong [3 ]
Huang, Zhen [1 ]
Dong, Jian [1 ]
机构
[1] Key Lab of Optic-Electronic and Communication, Jiangxi Sciences and Technology Normal University, Nanchang, 330038, Jiangxi
[2] Department of Physics and Engineering, Hunan University of Technology, Zhuzhou, 412000, Hunan
[3] Doppler Electronic Technologies Company Limited, Guangzhou, 510663, Guangdong
来源
Zhongguo Jiguang/Chinese Journal of Lasers | 2014年 / 41卷 / 10期
关键词
Biotechnology; Laser diode; Optical-resolution; Photoacoustic microscopy;
D O I
10.3788/CJL201441.1004001
中图分类号
学科分类号
摘要
A compact optical-resolution photoacoustic microscopy system is designed with a pulsed laser diode, which has the properties of being low cost, small size, robust and high repetition frequency. Typical photoacoustic images of carbon fiber and blood vessel phantoms are reconstructed clearly. During the experiments, the pulsed laser diode excitation is droved to implement C-mode scanning excitation with three-dimensional translation stage, and the excited photoacoustic signal is captured by a 1-3 composite ultra-bandwidth ultrasonic transducer. The photoacoustic signal-to-noise ratio is recorded of approximate 11 dB, and the lateral resolution of the current system is improved up to 1.5 μm from 500 μm of the first-generation system. The experimental results demonstrate that the proposal method has the potential to be developed as a configuration of inexpensive, real-time, portable, and high-resolution photoacoustic microscopy technique.
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页数:6
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  • [11] Cai Q., Tang Z., Wu Y., Et al., Microcavity photoacoustic detecting technology and imaging method, Acta Optica Sinica, 33, 9, (2013)
  • [12] Liu Y., Yang X., Luo Q., Method of sliding focus photoacoustic microscopic, Acta Optica Sinica, 32, 5, (2012)
  • [13] Yang X., Cai X., Maslov K., Et al., High-resolution photoacoustic microscope for rat brain imaging in vivo, Chin Opt Lett, 8, 6, pp. 609-611, (2010)
  • [14] Maslov K., Zhang H.F., Hu S., Et al., Optical-resolution photoacoustic microscopy for in vivo imaging of single capillaries, Opt Lett, 33, 9, pp. 929-931, (2008)
  • [15] Zhang C., Maslov K., Wang L.V., Subwavelength-resolution label-free photoacoustic microscopy of optical absorption in vivo, Opt Lett, 35, 19, pp. 3195-3197, (2010)
  • [16] Hu S., Maslov K., Wang L.V., Second-generation optical-resolution photoacoustic microscopy with improved sensitivity and speed, Opt Lett, 36, 7, pp. 1134-1136, (2011)
  • [17] Yao J., Maslov K., Puckett E.R., Et al., Double-illumination photoacoustic microscopy, Opt Lett, 37, 4, pp. 659-661, (2012)
  • [18] Yang J., Favazza C., Chen R., Et al., Simultaneous functional photoacoustic and ultrasonic endoscopy of internal organs in vivo, Nat Med, 18, 8, pp. 1297-1303, (2012)
  • [19] Wang L., Maslov K., Yao J., Et al., Fast voice-coil scanning optical-resolution photoacoustic microscopy, Opt Lett, 36, 2, pp. 139-141, (2011)
  • [20] Ye S., Yang R., Xiong J., Et al., Label-free imaging of zebrafish larvae in vivo by photoacoustic microscopy, Biomed Opt Express, 3, 2, pp. 360-365, (2012)