Advancing quinoxaline chemistry: Sustainable and green synthesis using L-arabinose as a catalyst

被引:0
作者
Detke, Sandip J. [1 ]
Karwande, Anuja D. [1 ]
Ponugoti, Sai Srinivas [1 ]
Joshi, Shreerang V. [1 ]
Kharkar, Prashant S. [1 ]
机构
[1] Inst Chem Technol, Dept Pharmaceut Sci & Technol, Nathalal Parekh Marg, Mumbai, India
关键词
Quinoxaline derivatives; L-arabinose; green chemistry; sustainable synthesis; catalysis; EFFICIENT SYNTHESIS; ALPHA-HYDROXYKETONES; RECYCLABLE CATALYST; RICE HUSK; DERIVATIVES; ACID; STRATEGIES; SOLVENTS;
D O I
10.1080/00397911.2024.2419861
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
In the present study, an innovative and eco-friendly methodology for synthesizing quinoxaline derivatives has been introduced, leveraging L-arabinose as a novel catalyst. This approach not only underscores the feasibility of green chemistry in synthesizing high-purity quinoxaline derivatives but also highlights the enhanced sustainability of the process. Detailed mechanistic investigations revealed the synergistic interactions between L-arabinose and the reactants, providing a deeper understanding of the catalytic process. The synthesized compounds, due to their unique structural and electronic properties, may find promising applications in life and material sciences such as optoelectronics. Furthermore, our environmental impact assessment demonstrated significant reduction in generated waste, solvent use, and overall carbon footprint, aligning with the global agenda for sustainable development. This research marks a significant step forward in quinoxaline chemistry, promoting the adoption of green synthesis pathways while reinforcing the principles of sustainable and environment-friendly chemical practices. [GRAPHICS] .
引用
收藏
页码:2024 / 2037
页数:14
相关论文
共 67 条
[1]   Recent Advances on Cellulose Sulfuric Acid as Sustainable and Environmentally Benign Organocatalyst for Organic Transformations [J].
Agarwal, Shalini ;
Lathwal, Ankit ;
Nath, Mahendra .
CURRENT ORGANOCATALYSIS, 2021, 8 (01) :72-92
[2]   Zirconium(IV) chloride as versatile catalyst for the expeditious synthesis of quinoxalines and pyrido[2,3-b]pyrazines under ambient conditions [J].
Aghapoor, Kioumars ;
Darabi, Hossein Reza ;
Mohsenzadeh, Farshid ;
Balavar, Yadollah ;
Daneshyar, Hesam .
TRANSITION METAL CHEMISTRY, 2010, 35 (01) :49-53
[3]   Chemistry and pharmacological diversity of quinoxaline motifs as anticancer agents [J].
Ajan, Olayinka O. ;
Nlebemuo, Martins T. ;
Adekoya, Joseph A. ;
Ogunniran, Kehinde O. ;
Siyanbola, Tolutope O. ;
Ajanaku, Christiana O. .
ACTA PHARMACEUTICA, 2019, 69 (02) :177-196
[4]   D-D-π-A-π-A-based quinoxaline dyes incorporating phenothiazine, phenoxazine and carbazole as electron donors: Synthesis, photophysical, electrochemical, and computational investigation [J].
Al-Marhabi, Aisha R. ;
El-Shishtawy, Reda M. ;
Bouzzine, Si Mohamed ;
Hamidi, Mohamed ;
Al-Ghamdi, Huda A. ;
Al-Footy, Khalid O. .
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY, 2023, 436
[5]   Green and Eco-friendly Synthetic Strategies for Quinoxaline Derivatives [J].
Ali, Irfan ;
Bhatia, Rohit .
CURRENT GREEN CHEMISTRY, 2024, 11 (01) :37-49
[6]   Proteomic and Functional Analysis of the Effects of Quinoxaline Derivatives on Entamoeba histolytica [J].
Avila-Bonilla, Rodolfo Gamaliel ;
Lopez-Sandoval, Angel ;
Soto-Sanchez, Jacqueline ;
Marchat, Laurence A. ;
Rivera, Gildardo ;
Medina-Contreras, Oscar ;
Ramirez-Moreno, Esther .
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, 2022, 12
[7]   Pterin chemistry and its relationship to the molybdenum cofactor [J].
Basu, Partha ;
Burgmayer, Sharon J. N. .
COORDINATION CHEMISTRY REVIEWS, 2011, 255 (9-10) :1016-1038
[8]  
Belen'kii LI, 2022, ADV HETEROCYCL CHEM, V136, P225, DOI 10.1016/bs.aihch.2021.09.002
[9]   Recent advances in the transition-metal-free synthesis of quinoxalines [J].
Borah, Biplob ;
Chowhan, L. Raju .
RSC ADVANCES, 2021, 11 (59) :37325-37353
[10]   A Review on Multipurpose Potential of Bioactive Heterocycle Quinoxaline [J].
Chawla, Gita ;
Gupta, Ojasvi ;
Pradhan, Tathagata .
CHEMISTRYSELECT, 2023, 8 (29)