Renewable energies will play a significant role in transitioning towards sustainable energy system in order to match the goal under the Paris Agreement. However, to achieve this goal, it will be necessary to find the best country pathway, with global repercussions. This study reveals that an energy system based on 100% renewable resources in Chile would be technically feasible and even more cost-efficient than the current system. The Chilean energy system transition would imply a high level of direct and indirect electrification across all sectors. Simulation results using the LUT Energy System Transition model comprising 108 technology components show that the primary electricity demand would rise from 31 TWh to 231 TWh by 2050, which represents about 78% of the total primary energy demand. The remaining 22% would be composed of renewable heat and bioenergy fuels. Renewable electricity will mainly come from solar PV and wind energy technologies. Solar PV and wind energy installed capacities across all sectors would increase from 1.1 GW and 0.8 GW in 2015 to 43.6 GW and 24.8 GW by 2050, respectively. In consequence, the levelized cost of energy will reduce by about 25%. Moreover, the Chilean energy system in 2050 would emit zero greenhouse gases. Additionally, Chile would become a country free of energy imports. © 2020, Aalborg University press. All rights reserved.