Changes in ESR-spectra of the model nitrozyl complexes with blood hemoproteins after low-dose irradiation of mice

被引：0

作者：

Mil, E.M. ^{[1
]}

Kasparov, V.V. ^{[1
]}

Binukov, V.I. ^{[1
]}

Tabatchikova, N.V. ^{[1
]}

Borisova, O.A. ^{[1
]}

机构：

[1] Inst. Biokhimicheskoj Fiziki, RAN, Moscow, Russia

来源：

Radiatsionnaya Biologiya. Radioekologiya | 2000年 / 40卷 / 03期

关键词：

Animal cell culture - Blood - Hemoglobin - Ionizing radiation - Nitrogen oxides - Paramagnetic resonance;

D O I：

暂无

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学科分类号：

摘要：

After NO adding to mice blood and isolated erythrocytes ESR signal of nitrozyl complex HbNO (g=2.07, g=1.98) and NO-induced MetNg (g=6.0) were registered. It was shown that the intensity of ESR spectra of these complexes increased after radiation of mice with a dose of 0.06, 0.6 and 5.4 cGy. Low-dose irradiation (0.6 and 0.06 cGy) caused the change in the form of ESR spectra of HbNO (g=2.07), which is indicative of the shift from T-structure to R-structure and of the preferred formation of R-conformations of oxyhemoglobin in blood. It was found that dependence of NO-induced MetHb signal on irradiation dose is bimodal that may be connected with nonlinear response of the cells to irradiation and retarded adaptive response after radiation with low doses.

引用

页码：305 / 309