Random and aligned PLLA: PRGF electrospun scaffolds for regenerative medicine

被引：0

作者：

20150700528948

机构：

[1] Díaz-Gómez, Luis

[2] Ballarin, Florencia Montini

[3] Abraham, Gustavo A.

[4] Concheiro, Angel

[5] Alvarez-Lorenzo, Carmen

来源：

Abraham, Gustavo A. (gabraham@fi.mdp.edu.ar) | 1600年 / John Wiley and Sons Inc卷 / 132期

关键词：

Random and aligned electrospun scaffolds were prepared combining poly(L-lactic acid) (PLLA) and activated platelet-rich plasma (PRGF) at various proportions; with the aim of elucidating the role of nanofibers orientation and growth factors on cell attachment and proliferation. PRGF is released from scaffolds in a sustained way for at least 3 weeks; without an initial burst effect. Mesenchymal stem cells (MSCs) seeded on the random scaffolds present a polygonal and random orientation in any direction of the scaffold. On the other hand; aligned scaffolds are able to promote cell attachment and proliferation in the direction of the nanofibers. The incorporation of PRGF in the scaffolds enhances cell proliferation for at least 2 weeks. Overall; aligned electrospun PLLA : PRGF scaffolds can encapsulate growth factors at relatively large proportions and sustain their release to enhance cell attachment and proliferation as well as eliciting cell alignment. © 2014 Wiley Periodicals; Inc;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

引用