Adipose tissue remodeling and chronic inflammation in obesity visualized by in vivo molecular imaging method

被引：2

作者：

Nishimura S. ^{[1
,2
,3
]}

Nagasaki M. ^{[1
,4
]}

机构：

[1] Department of Cardiovascular Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113-0033

[2] Translational Systems Biology and Medicine Initiative, University of Tokyo, Tokyo

[3] PRESTO, Japan Science and Technology Agency, Tokyo

[4] Computational Diagnostic Radiology and Preventive Medicine, University of Tokyo, Tokyo

来源：

Journal of Biorheology | 2010年 / 24卷 / 01期

关键词：

Adipogenesis; Adipose tissue; Angiogenesis; In vivo molecular imaging method; Inflammation; Metabolic diseases;

D O I：

10.1007/s12573-010-0020-1

中图分类号：

学科分类号：

摘要：

Obese visceral adipose tissue remodeling and dysfunction, based on chronic inflammation and local immunological changes, play major roles in the metabolic syndrome. Therefore, an in vivo visualization technique has been developed to assess the dynamic interplay between multiple cell types in obese adipose. In vivo imaging revealed close spatial and temporal interrelationships between angiogenesis and adipogenesis, which were augmented in obese adipose tissue. In addition, increased leukocyte-platelet-endothelial cell interactions were observed in the microcirculation, a hallmark of inflammation. Upregulated expression of adhesion molecules contribute to the local activation of inflammatory processes. We also found that large numbers of CD8+ effector T cells infiltrated into the obese adipose tissue, playing major roles in inflammatory macrophage infiltration into obese adipose tissue, the induction and maintenance of inflammation, and systemic insulin resistance. Our results demonstrate the power of our imaging technique to analyze multi-cellular interactions in inflammation in vivo and to evaluate new therapeutic interventions. © 2010 Japanese Society of Biorheology.

引用

页码：11 / 15

页数：4

共 7 条

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