Adiponectin: No longer the lone soul in the fight against insulin resistance?

被引：44

作者：

Davis, Kathryn E. ^{[1
]}

Scherer, Philipp E. ^{[1
,2
]}

机构：

[1] Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX 75390, United States

[2] Department of Cell Biology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, United States

来源：

Biochemical Journal | 2008年 / 416卷 / 02期

关键词：

D O I：

10.1042/BJ20082033

中图分类号：

学科分类号：

摘要：

Adiponectin is one of the most effective adipokines in the context of correcting obesity-induced insulin resistance. However, adiponectin-deficient animal models show a relatively modest phenotype unless metabolically challenged. This suggests that potent compensatory mechanisms are in place. In this issue of the Biochemical Journal, Wong et al. characterize new members of the CTRPs [C1q-TNFα (tumour necrosis factor α)-related proteins]. They establish that some CTRPs are produced primarily in the stromal vascular fraction of adipose tissue, and that expression of CRTP1, in particular (like adiponectin), is induced by PPARγ (peroxisome-proliferator-activated receptor γ) agonists. Moreover, injection of recombinant CTRP1 displays glucose-lowering effects. These observations suggest that CTRP1 may have partially overlapping functions and, along with other paralogues, may effectively compensate for the chronic loss of adiponectin function. © The Authors Journal compilation.

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