Synergistic effects of implant macrogeometry and surface physicochemical modifications on osseointegration: An in vivo experimental study in sheep

被引：4

作者：

Bergamo E.T.P. ^{[1
]}

de Oliveira P.G.F.P. ^{[2
]}

Jimbo R. ^{[3
]}

Neiva R. ^{[4
]}

Tovar N. ^{[5
]}

Witek L. ^{[5
,6
]}

Gil L.F. ^{[7
]}

Bonfante E.A. ^{[1
]}

Coelho P.G. ^{[5
,6
,8
]}

机构：

[1] Department of Prosthodontics and Periodontology, Bauru School of Dentistry, University of Sao Paulo, Bauru, SP

[2] Periodontology Department, School of Dentistry, University Center of State of Para, Belem, PA

[3] Regenerative Oral Surgery Department, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki

[4] Periodontology Department, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA

[5] Department of Biomaterials and Biomimetics, New York University, New York, NY

[6] Department of Biomedical Engineering, New York University Tandon School of Engineering Brooklyn, New York, NY

[7] Dentistry Department, Federal University of Santa Catarina, Florianopolis, SC

[8] Department of Plastic Surgery, New York University Grossman School of Medicine, New York, NY

来源：

Journal of Long-Term Effects of Medical Implants | 2019年 / 29卷 / 04期

基金：

巴西圣保罗研究基金会;

关键词：

Dental implants; Design; Osseointegration; Surface treatment;

D O I：

10.1615/JLongTermEffMedImplants.2020034194

中图分类号：

学科分类号：

摘要：

This study evaluates the influence of two surface physicochemical modifications on osseointegration parameters of a healing chamber implant design. We examine dental implants with internal and external trapezoidal threads that have the following surface modifications: dual acid etching (DAE) and nano-hydroxyapatite (HA) coating over DAE surface (Nano). We installed implants in the right ilium of sheep and conducted histologic/metric analyses after 3 and 12 wk in vivo. We quantified the percentage of bone-to-implant contact (%BIC) and bone area fraction occupancy (%BAFO) within implant threads. Histologic micrographs indicate early bone formation within the healing chambers of implants with Nano surface relative to DAE surface. Histomorphometric analysis demonstrates there to be no significant differences in %BIC between 3 and 12 wk (p = 0.298). Compared to DAE, Nano shows more bone formation in contact with implant, regardless of time (p < 0.025). We observe > %BAFO at 12 wk relative to 3 wk, which differs significantly for Nano (p < 0.038). Implant surface treatment affects the amounts of bone formation within healing chambers, with Nano significantly outperforming DAE at 12 wk (p < 0.025). Nano presents a synergistic effect with implant design, improving osseointegration parameters. © 2019 by Begell House, Inc.

引用

页码：295 / 302

页数：7

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