Diamond Devices for High Acuity Prosthetic Vision

被引：44

作者：

Ahnood A. ^{[1
]}

Meffin H. ^{[2
,3
]}

Garrett D.J. ^{[1
]}

Fox K. ^{[1
,4
]}

Ganesan K. ^{[1
]}

Stacey A. ^{[1
]}

Apollo N.V. ^{[1
]}

Wong Y.T. ^{[2
,5
]}

Lichter S.G. ^{[1
]}

Kentler W. ^{[5
]}

Kavehei O. ^{[4
]}

Greferath U. ^{[6
]}

Vessey K.A. ^{[6
]}

Ibbotson M.R. ^{[2
,3
]}

Fletcher E.L. ^{[6
]}

Burkitt A.N. ^{[5
]}

Prawer S. ^{[1
]}

机构：

[1] School of Physics, University of Melbourne, 3010, VIC

[2] National Vision Research Institute, Australian College of Optometry, 3053, VIC

[3] ARC Centre of Excellence for Integrative Brain Function Department of Optometry and Vision Science, University of Melbourne, 3010, VIC

[4] School of Engineering, RMIT University, Melbourne

[5] Department of Electrical & Electronic Engineering, The University of Melbourne, 3010, VIC

[6] Department of Anatomy and Neuroscience, University of Melbourne, 3010, VIC

来源：

Advanced Biosystems | 2017年 / 1卷 / 1-2期

基金：

英国医学研究理事会; 澳大利亚研究理事会;

关键词：

diamond electrodes; diamond encapsulation; high acuity; neuronal stimulators; retinal implants;

D O I：

10.1002/adbi.201600003

中图分类号：

学科分类号：

摘要：

Retinal implants restore a sense of vision, for a growing number of users worldwide. Nevertheless, visual acuities provided by the current generation of devices are low. The quantity of information transferable to the retina using existing implant technologies is limited, far below receptor cells' capabilities. Many agree that increasing the information density deliverable by a retinal prosthesis requires devices with stimulation electrodes that are both dense and numerous. This work describes a new generation of retinal prostheses capable of upscaling the information density conveyable to the retina. Centered on engineered diamond materials, the implant is very well tolerated and long-term stable in the eye's unique physiological environment and capable of delivering highly versatile stimulation waveforms – both key attributes in providing useful vision. Delivery of high-density information, close to the retina with the flexibility to alter stimulation parameters in situ provides the best chance for success in providing high acuity prosthetic vision. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

引用

页码：1 / 2

共 55 条

[1]

Zrenner E., Science, 295, (2002)

[2]

Humayun M.S., Dorn J.D., da Cruz L., Dagnelie G., Sahel J.-A., Stanga P.E., Cideciyan A.V., Duncan J.L., Eliott D., Filley E., Ho A.C., Santos A., Safran A.B., Arditi A., Del Priore L.V., Greenberg R.J., Ophthalmology, 119, (2012)

[3]

Stingl K., Bartz-Schmidt K.U., Besch D., Chee C.K., Cottriall C.L., Gekeler F., Groppe M., Jackson T.L., MacLaren R.E., Koitschev A., Kusnyerik A., Neffendorf J., Nemeth J., Naeem M.A.N., Peters T., Ramsden J.D., Sachs H., Simpson A., Singh M.S., Wilhelm B., Wong D., Zrenner E., Vision Res., 111, (2015)

[4]

Ayton L.N., Blamey P.J., Guymer R.H., Luu C.D., Nayagam D.A.X., Sinclair N.C., Shivdasani M.N., Yeoh J., McCombe M.F., Briggs R.J., Opie N.L., Villalobos J., Dimitrov P.N., Varsamidis M., Petoe M.A., McCarthy C.D., Walker J.G., Barnes N., Burkitt A.N., Williams C.E., Shepherd R.K., Allen P.J., PLoS One, 9, (2014)

[5]

Guymer R., Brandli A., Luu C., Ayton L., Eye Brain, 8, (2016)

[6]

Chader G.J., Weiland J., Humayun M.S., Prog. Brain Res., 175, (2009)

[7]

Shivdasani M.N., Luu C.D., Cicione R., Fallon J.B., Allen P.J., Leuenberger J., Suaning G.J., Lovell N.H., Shepherd R.K., Williams C.E., J. Neural Eng., 7, (2010)

[8]

Villalobos J., Allen P.J., McCombe M.F., Ulaganathan M., Zamir E., Ng D.C., Shepherd R.K., Williams C.E., Albrecht Von Graefes Arch. Klin. Exp. Ophthalmol., 250, (2012)

[9]

Villalobos J., Nayagam D.A.X., Allen P.J., McKelvie P., Luu C.D., Ayton L.N., Freemantle A.L., McPhedran M., Basa M., McGowan C.C., Shepherd R.K., Williams C.E., Invest. Ophthalmol. Vis. Sci., 54, (2013)

[10]

Stingl K., Bartz-Schmidt K.U., Besch D., Braun A., Bruckmann A., Gekeler F., Greppmaier U., Hipp S., Hortdorfer G., Kernstock C., Koitschev A., Kusnyerik A., Sachs H., Schatz A., Stingl K.T., Peters T., Wilhelm B., Zrenner E., Proc. R. Soc. B, 280, (2013)

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