Preparation and Drug Release of UV-Polymerized pH Sensitive Hydrogels

被引：0
|
作者：
Yang B. [1 ]
Hou P. [2 ]
Zhang H. [1 ]
Hou Z. [2 ]
机构：
[1] Key Laboratory of Public Security Management Technology in Universities of Shandong, Shandong Management University, Jinan
[2] College of Chemistry, Chemical Engineering and Materials Science, Shandong Normal University, Jinan
来源：
Gaofenzi Cailiao Kexue Yu Gongcheng/Polymeric Materials Science and Engineering | 2019年 / 35卷 / 04期
关键词：
Drug release; PH sensitive hydrogel; UV-polymerization;
D O I：
10.16865/j.cnki.1000-7555.2019.0096
中图分类号：
学科分类号：
摘要：
In this paper, a novel biodegradable pH sensitive hydrogel was prepared by ultra violet-induced free radical polymerization using 4-arm-poly(ethylene glycol) -poly(ε-caprolactone)-acrylate (4-arm-PEG-PCL-AC) and methacrylic acid ( MAA) as crosslinking monomer. The chemical structure of the macromonomer was characterized by IR and 1H-NMR. The morphologies of the dried pH sensitive hydrogels were observed by scanning electron microscope, and the swelling ratio, in vitro degradation and drug release properties of the hydrogels were systematically studied. The results show that the pH sensitivity, equilibrium swelling ratio, drug release rate increase with the increment of medium pH value, and the pH sensitivity and equilibrium swelling ratio also increase with the increment of MAA content in hydrogel. At pH=7.4, the drug release rate and in vitro degradation rate increase with the increment of MAA content. The pH sensitive hydrogels possess a good biocompatibility, pH sensitivity, biodegradability an d controlled drug release, which allow it to be used in drug delivery system and improve the application of hydrogels in biomedical field. © 2019, Editorial Board of Polymer Materials Science & Engineering. All right reserved.
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页码：19 / 25
页数：6
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