Psychopharmacological and analgesic action of selective serotonin reuptake inhibitor antidepressants fluoxetine in female mouse

被引：0

作者：

Cobo-Realpe L. ^{[1
]}

Collazos C.A. ^{[2
]}

Castellanos H.E. ^{[2
]}

Herrera-Mendoza K. ^{[3
]}

机构：

[1] Grupo Biopsiquismo y Sociedad, Universidad Manuela Beltrán, Bogotá D.C

[2] Grupo de Ciencias Básicas y Laboratorios, Universidad Manuela Beltrán, Bogotá D.C.

[3] Grupo de Investigación Cultura, Educación y Sociedad, Programa de psicología, Universidad de la Costa CUC, Barranquilla

来源：

Informacion Tecnologica | 2020年 / 31卷 / 03期

关键词：

Analgesic; Antidepressant; Fluoxetine; Selective serotonin reuptake inhibition;

D O I：

10.4067/S0718-07642020000300039

中图分类号：

学科分类号：

摘要：

The main objective of this paper is to establish the potency range and the action mechanism of selective serotonin reuptake inhibition (SSRI) fluoxetine on female CD-1 mice (25-39 kg). Our results indicated that fluoxetine´s antidepressant doses of 16 mg/kg (i.p.), 32 mg/kg (i.p.), and 64 mg/kg (i.p.) had an analgesic and anxiolytic effect without significant results on the spatial memory test. Reduced activity on memory work on specific activities was only observed with a dose of 64 mg/kg (i.p.). This is evidence to suggest that fluoxetine can be more effective with doses that showed an antidepressant effect. It also indicates that fluoxetine can have an analgesic and anxiolytic effect without reducing motor activity on mice. The maximum dose tested on this study showed variations on motor activity of mice suggesting that SSRI fluoxetine can have sedative effects. © 2020 Centro de Informacion Tecnologica. All rights reserved.

引用

页码：39 / 50

页数：11

共 29 条

[1] Abello-Luque D., Cortes-Pena. O y otros 4 autores. “Escala Multidimensional de Trastornos Afectivos, EMTA: Generacion de Indicadores Psicometricos y Escalas Normativas de Uso Clinico, Revista Iberoamericana de Diagnostico y Evaluacion, 43, 1, pp. 187-198, (2017)
[2] Allegri R., Pertierra L., A biological classification for Alzheimer's disease - Amyloid, Tau and Neurodegeneration (A/T/N): results from the Argentine-Alzheimer's Disease Neuroimaging Initiative, (2019)
[3] Barcelo-Martinez E., Gelves-Ospina M., Niveles de cortisol serico y alteraciones neuropsicologicas en pacientes con diagnostico de Fibromialgia, Actas Españolas de Psiquiatria, 46, 1, pp. 1-11, (2018)
[4] Berrocoso E., Cooperative Opioid and Serotonergic Mechanisms Generate Superior Antidepressant-like Effects in a Mice Model of Depression, International Journal of Neuropsychopharmacology, 12, pp. 1033-1044, (2009)
[5] Castagne V., Moser P., Rodent Models of Depression: Forced Swim and Tail Suspension Behavioral Despair Tests in Rats and Mice, pp. 1-14, (2011)
[6] Cobo-Realpe B.L., Antidepressant Drugs and Pain, Effects of Antidepressants, pp. 143-162, (2012)
[7] Collier J, The Abdominal Constriction Response and its Suppression by Analgesic Drugs in the Mouse, Br. J. Pharmac. Chemother, 32, (1968)
[8] Delgado-Moreno R., Robles-Perez J., Effect of Experience and Psychophysiological Modification by Combat Stress in Soldier's Memory, Journal of Medical Systems, 43, (2019)
[9] Gamil N. M., Modulatory Effect of Cilostazol on Tramadol-Induced Behavioral and Neurochemical Alterations in Rats Challenged across the Forced Swim Despair Test, Journal of Basic and Applied Sciences, 5, 2, pp. 193-201, (2016)
[10] Grassi G., Atomoxetine for Hoarding Disorder: A Pre-Clinical and Clinical Investigation, Journal of Psychiatric Research, 83, pp. 240-248, (2016)

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