Lidocaine/β-cyclodextrin inclusion complex as drug delivery system

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[1] Abou-Okeil, A.
[2] Rehan, M.
[3] El-Sawy, S.M.
[4] El-bisi, M.K.
[5] Ahmed-Farid, O.A.
[6] Abdel-Mohdy, F.A.
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Abou-Okeil, A. (aokeil2004@yahoo.com) | 1600年 / Elsevier Ltd卷 / 108期
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Lidocaine (LC)/β-cyclodextrin (β-CD) inclusion complex was prepared. This complex was confirmed using, UV–vis spectroscopy, Fourier-transform infrared spectroscopy (FTIR), thermal gravimetric analysis (TGA) and scanning electron microscope (SEM). This complex was used to prepare hydrogel to be used as topical pain relief. (GII) and compared with gel contains Lidocaine (GI) only. The prepared gel was evaluated by measuring the spreadability, moisture regain, viscosity, pH and drug release profile. The results received showed that the gel properties were improved by introducing the Lidocaine/β-cyclodextrin inclusion complex. The release profiles revealed that, gel with Lidocaine/β-cyclodextrin inclusion complex showed improved sustained release behaviour. © 2018 Elsevier Ltd
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